Seung Hwan Yoon

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To assess the safety and therapeutic efficacy of autologous human bone marrow cell (BMC) transplantation and the administration of granulocyte macrophage-colony stimulating factor (GM-CSF), a phase I/II open-label and nonrandomized study was conducted on 35 complete spinal cord injury patients. The BMCs were transplanted by injection into the surrounding(More)
Recently, we reported that GM-CSF showed therapeutic effects on the spinal cord injury (SCI) in rat model possibly via its anti-apoptotic activity in the nervous system. This study investigated the molecular mechanism of its anti-apoptotic and neuroprotective effects in N2a neuroblastoma cells and in rat SCI model. GM-CSF inhibited staurosporine-induced(More)
STUDY DESIGN This was a radiographic reliability study of a novel grading system for cervical intervertebral disc degeneration. OBJECTIVES This study aimed to develop and test the reliability of a reproducible grading system for cervical intervertebral disc degeneration on the basis of the routine magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND(More)
STUDY DESIGN Rat spinal fusion model. OBJECTIVE This study aimed to compare the efficacy of lentiviral gene therapy, and adenoviral gene therapy in inducing spinal fusion in an immune competent rat spinal fusion model. SUMMARY OF BACKGROUND DATA Recombinant bone morphogenetic proteins (BMPs) have also been used for spinal fusion successfully in clinical(More)
STUDY DESIGN Rat spinal fusion model. OBJECTIVE To compare the efficacy of human adipose tissue-derived mesenchymal stem cells (HATDMSCs) and human bone marrow-derived mesenchymal stem cells (HBMDMSCs) transduced with an adenovirus containing the cDNA for bone morphogenetic proteins (BMP)-2 for inducing spinal fusion in an athymic rat model. SUMMARY OF(More)
STUDY DESIGN Kinetic MRIs of cervical spines were obtained and analyzed according to the amount of motion and the degenerative grade of the intervertebral disc. OBJECTIVE To define the relationship between the grade of disc degeneration and the motion unit of the cervical spine and elucidate changes in the role of each cervical spine unit during(More)
GM-CSF is recently being suggested to play important role(s) in the nervous system. Present study was intended to understand signal transduction pathways of GM-CSF in human neuroblastoma (SK-N-(BE)2) and glioblastoma (A172) cell lines. The expression of GM-CSF receptors on the surface of these cells was confirmed by immunocytochemistry, Western blot(More)
STUDY DESIGN Prospective study comparing the somatometric measurements of young males with normal spinal curves and with adolescent idiopathic scoliosis (AIS) with respect to the severity of AIS. OBJECTIVE To assess the somatometric measurements of young males with normal spinal curves and with AIS using the conscription data. SUMMARY OF BACKGROUND DATA(More)
OBJECTIVE The authors investigated the changes of cortical sensorimotor activity in functional MRI (fMRI) and functional recovery in spinal cord injury (SCI) patients who had been treated by bone marrow cell transplantation. METHODS Nineteen patients with SCI were included in this study; ten patients with clinical improvement and nine without. The(More)
OBJECTIVE Granulocyte macrophage colony stimulating factor (GM-CSF) is a potent hematopoietic cytokine, which stimulates stem cell proliferation in the bone marrow and inhibits apoptotic cell death in leukocytes. However, the effects of GM-CSF in the central nervous system are still unclear. The present study was undertaken to determine if GM-CSF can rescue(More)