Seung-Ho Hong

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The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following(More)
Apolipoprotein A1 (ApoA1) plays an important role in reverse cholesterol transport. The functional abnormality of ApoA1 is known to be the major risk for lipid disorders or cardiovascular diseases. In this study, we examined the associations of two ApoA1 polymorphisms (XmnI and MspI/rs670) with the Korean patients with metabolic syndrome (MetS). A total of(More)
AIMS Polymorphisms in microRNA (miR) genes are thought to be associated with various cancers and vascular diseases. To date, however, the effects of the miR gene polymorphisms on susceptibility to hypertension have rarely been investigated. In this study, we investigated the associations of three miR gene polymorphisms (miR-146aC>G/rs2910164,(More)
Classical swine fever virus (CSFV) causes a highly contagious disease among swine that has an important economic impact worldwide. CSFV strain LOM is an attenuated virus of low virulent strain of Miyagi isolated from Japan in 1956. Eight DNA fragments representing the genome of the CSFV strain LOM were obtained by RT-PCR. These were used to determine the(More)
This paper presents an adaptive predistortion RF power amplifier for repeater systems with a spectrum monitor. For adaptive control of cancellation, we implement a spectrum monitor that improves the adjacent channel leakage ratio (ACLR) characteristics of the power amplifier by analyzing the output spectrums of RF power amplifiers directly and(More)
Aldosterone synthase plays an important role in determining the levels of aldosterone secretion. Polymorphisms of the aldosterone synthase gene (CYP11B2) are suggested to be associated with essential hypertension. In this study, we examined associations of CYP11B2 polymorphisms [−344T/C, K173R and intron 2 conversion (IC)] with Korean hypertensive patients.(More)
Replication of the hepatitis B virus is suppressed by deficiency of the X protein. Although several molecules that block cellular targets of X protein reduce the production of hepatitis B virus progeny, the effect of a specific inhibitor of X protein on viral replication has not been investigated. To block X protein specifically, we adopted an intracellular(More)
We developed a new phagemid system for the generation of combinatorial antibody libraries. This system allows the recombination efficiency to be estimated easily, which aids the accurate measurement of the antibody library size. Two phagemids were constructed. pRTCB bears the structural tetracycline-resistant gene (tetR) and pRTCA bears its promoter region(More)
AIMS Functional defects of the ApoA5 protein have been identified as risk factors for hypertriglyceridemia, vascular diseases and susceptibility to metabolic syndrome (MetS). These associations are neither strong nor consistent in all populations studied. In this study, we investigated the association between the ApoA5 -1131T>C and -12,238T>C polymorphic(More)
BACKGROUND T cell immunoglobulin and mucin domain containing 3 protein (Tim-3) expressed on terminally differentiated Th1 cells plays a suppressive role in Th1-mediated immune responses. Recently, it has been shown that N-glycosylation affects the binding activity of the Tim-3-Ig fusion protein to its ligand, galectin-9, but the binding properties of(More)