Seung-Hee Ryu

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Genes regulated by cyclic AMP–response element-binding protein (CREB) have been reported to suppress apoptosis, induce cell proliferation, and mediate inflammation and tumor metastasis. However, it is not clear whether CREB is critically involved in lung carcinogenesis. We found that non– small cell lung cancer (NSCLC) cell lines exhibited elevated(More)
Here we demonstrated that SKI2162, a small-molecule inhibitor of the TGF-β type I receptor (ALK5), prevented radiation-induced fibrosis (RIF) in mice. SKI2162 inhibited phosphorylation of Smad and induction of RIF-related genes in vitro. In RIF a mouse model, SKI2162 reduced late skin reactions and leg-contracture without jeopardizing the acute skin(More)
Lung adenocarcinoma, the most common subtype of lung cancer, is the leading cause of cancer death worldwide. Despite attempts for the treatment of lung cancer which have been accumulating, promising new therapies are still needed. Here, we found that cyclic-AMP response element-binding protein (CREB)-CREB binding protein (CBP) transcription factors complex(More)
Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and(More)
Radiation-induced oral mucositis is probably the most common toxicity for head and neck cancer patients. This adverse effect potentially leads to various lesions such as erythema, ulcerations, pain, opportunistic infections, and weight loss. Although there are many experimental studies and clinical trials related to novel therapies for radiation-induced(More)
  • Seung-Hee Ryu, Jung-Hoon Ahn, Kwang-Seung Cho, Byoung-Kuk Lee
  • 2015
– In this paper, a single-switch ZVZCS quasi-resonant CLL isolated DC-DC converter for driving a low-ower (less than 100 W) 32 " LED backlighting liquid crystal display television (LCD TV) is proposed. The proposed converter exhibits both forward and flyback operational characteristics. All semiconductors are activated and deactivated under the soft(More)
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