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Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1.

• Jeffrey W. Corbett, Seung-Bum Ko, +11 authors Susan K Erickson-Viitanen
• Antimicrobial agents and chemotherapy
• 1999

A research program targeted toward the identification of expanded-spectrum nonnucleoside reverse transcriptase inhibitors which possess increased potency toward K103N-containing mutant human… (More)

Studies on blackfoot disease and chronic arsenism in southern Taiwan: with special reference to skin lesions and fluorescent substances.

• H. S. Yu, H. M. Sheu, +5 authors C. S. Chen
• The Journal of dermatology
• 1984

18.1 A 20nm 9Gb/s/pin 8Gb GDDR5 DRAM with an NBTI monitor, jitter reduction techniques and improved power distribution

• Hye-Yoon Joo, Seung-Jun Bae, +14 authors Gyo-Young Jin
• 2016 IEEE International Solid-State Circuits…
• 2016

A 9Gb/s/pin 8Gb GDDR5 DRAM is implemented using a 20nm CMOS process. To cover operation up to 9Gb/s, which is the highest data-rate among implemented GDDR5 DRAMs [1], this work includes an NBTI… (More)

The increase in intracellular free calcium associated with IgG gamma 2b/gamma 1 Fc receptor-ligand interactions: role in phagocytosis.

• J. D. Young, Seung-Bum Ko, Zanvil Alexander Cohn
• Proceedings of the National Academy of Sciences…
• 1984

The concentration of cytosolic free calcium, [Ca2+]i, was measured in J774 mouse macrophages by use of the fluorescent indicator quin-2. Resting [Ca2+]i was 87 nM. Addition of a number of specific… (More)

Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate.

• Roberto Fischer, James M. Trzaskos, Ron L Magolda, Seung-Bum Ko, C S Brosz, Bjørn Mejdell Larsen
• The Journal of biological chemistry
• 1991

Conditions have been identified which permit metabolic formation of the third oxidized intermediate in the lanosterol 14 alpha-methyl demethylase reaction cascade. Metabolism of either the immediate… (More)

Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.

• M. Patel, Seung-Bum Ko, +7 authors Steven P. Seitz
• Bioorganic & medicinal chemistry letters
• 1999

Efavirenz (SUSTIVA) is a potent non-nucleoside reverse transcriptase inhibitor. Due to the observation of breakthrough mutations of the reverse transcriptase enzyme during Efavirenz therapy, we… (More)

Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.

• Jennifer Rodgers, Patrick Lam, +15 authors Susan K Erickson-Viitanen
• Chemistry & biology
• 1998

BACKGROUND Recent clinical trials have demonstrated that HIV protease inhibitors are useful in the treatment of AIDS. It is necessary, however, to use HIV protease inhibitors in combination with… (More)

Human podoplanin-positive monocytes and platelets enhance lymphangiogenesis through the activation of the podoplanin/CLEC-2 axis.

• Jin Hur, Jae Hee Jang, +11 authors Hyo Soo Kim
• Molecular therapy : the journal of the American…
• 2014

Emerging studies suggested that murine podoplanin-positive monocytes (PPMs) are involved in lymphangiogenesis. The goal of this study was to demonstrate the therapeutic lymphangiogenesis of human… (More)

Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents.

• M. Patel, Jennifer Rodgers, +6 authors Seung-Bum Ko
• Bioorganic & medicinal chemistry letters
• 1999

The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to… (More)

Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors.

• Jeffrey W. Corbett, Lorie Gearhart, +4 authors Susan K Erickson-Viitanen
• Bioorganic & medicinal chemistry letters
• 2000

Benzothiadiazine non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV have been synthesized via a novel process to afford active inhibitors, with the most potent compound exhibiting an… (More)

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