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Secondary metabolite (SM) production in filamentous fungi is mechanistically associated with chromatin remodeling of specific SM clusters. One locus recently shown to be involved in SM suppression in Aspergillus nidulans was CclA, a member of the histone 3 lysine 4 methylating COMPASS complex. Here we examine loss of CclA and a putative H3K4 demethylase,(More)
Corn silk (CS) has long been consumed as a traditional herb in Korea. Maysin is a major flavonoid of CS. The effects of maysin on macrophage activation were evaluated, using the murine macrophage RAW 264.7 cells. Maysin was isolated from CS by methanol extraction, and preparative C18 reverse phase column chromatography. Maysin was nontoxic up to 100 μg/ml,(More)
The aim of this study was to investigate the effects of formulation vehicles on the pharmacokinetics of docetaxel. The following three formulations of docetaxel were prepared to compare the pharmacokinetic profiles of docetaxel: Tween® 80 formulation (a vehicle composition of Taxotere®), Cremophor® EL formulation (a vehicle composition of Taxol®) and DMSO(More)
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