Seth Zuckerman

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This paper extends the survivor analysis of medical practice provided by Frech and Ginsburg (1974). Changes in the distribution of medical practice sizes are examined for the periods 1965-69, 1969-75, and 1975-80. Through 1975, we find that, almost uniformly, all sizes of medical groups were found to be optimal. In particular, the optimality of large (100(More)
Efficacy of conventional opioids can be limited by adverse events (AEs). TRV130 is a structurally novel biased ligand of the μ-opioid receptor that activates G protein signaling with little β-arrestin recruitment. In this phase 2, randomized, placebo- and active-controlled study, we investigated the efficacy and tolerability of TRV130 in acute pain after(More)
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