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The pregnancy-specific beta 1-glycoproteins (PSG) form the major group of proteins synthesized in the human placenta. There are over 30 proteins in the family, encoded by 11 genes located on chromosomes 19q13.1-13.3. The genes can be divided into three subgroups based on the C-terminal exons expressed. The subgroup 1 genes have been well characterized. In(More)
Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections are associated with unsafe injection practices, drug diversion, and other exposures to blood and are difficult to detect and investigate. Here, we developed and validated a simple approach for molecular detection of HCV(More)
The role of Homeobox transcription factors during fin and limb development have been the focus of recent work investigating the evolutionary origin of limb-specific morphologies. Here we characterize the expression of HoxD genes, as well as the cluster-associated genes Evx2 and LNP, in the paddlefish Polyodon spathula, a basal ray-finned fish. Our results(More)
Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections associated with unsafe injection practices, drug diversion, and other exposures to blood are difficult to detect and investigate. Molecular analysis has been frequently used in the study of HCV outbreaks and transmission chains;(More)
Molecular analysis has become one of the major tools used for viral outbreak investigation and transmission network inference. We present two novel methods for accurate identification of transmission clusters and sources of infection for highly heterogeneous viruses such as HIV and HCV. Validation on data obtained from HCV outbreaks shows that the proposed(More)
Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections associated with unsafe injection practices, drug diversion, and other exposures to blood are difficult to detect and investigate. Molecular analysis has been frequently used in the study of HCV outbreaks and transmission chains;(More)
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