Seth Goodman

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To estimate the incidence, prevalence, and economic burden of secondary breast cancer brain metastases (BCBM) among a US-based population of patients with primary breast cancer. Female patients diagnosed with secondary BCBM between 1/2002 and 12/2004 and with a brain or head diagnostic test within 30 days of the BCBM diagnosis were identified in a US(More)
OBJECTIVES Because clinical guidelines do not offer clear recommendations for treatment options after discontinuing a tumor necrosis factor (TNF) blocker, this study evaluated treatment patterns within 360 days after discontinuation of TNF-blocker treatment. METHODS The IMS LifeLink Health Plan Claims database was used to identify patients diagnosed with(More)
OBJECTIVE To calculate annual cost per treated patient of tumor necrosis factor (TNF) inhibitors etanercept, adalimumab, and infliximab for common approved indications, based on actual TNF-inhibitor use in clinical practice. METHODS Adults with ≥1 claim for etanercept, adalimumab, or infliximab between January 2005 and March 2009 were identified from the(More)
Our purpose is to compare cobinamide to hydroxocobalamin in reversing cyanide (CN)-induced physiologic effects in an animal model using diffuse optical spectroscopy (DOS). Cyanide poisoning is a major threat worldwide. Cobinamide is a novel molecule that can bind two molecules of cyanide, has a much higher binding affinity than hydroxocobalamin, and is more(More)
BACKGROUND Patterns of therapy switching in patients receiving long-acting opioids have not been well documented. OBJECTIVE To compare therapy switching among patients beginning treatment with controlled-release (CR) oxycodone, transdermal fentanyl, or CR morphine sulfate. METHODS Using a US healthcare claims database, we identified patients beginning(More)
This study analyzes the complex rhetorical practice of hashtag use across social media platforms and emphasizes the implications for UX designers and technical communicators working with social media. Specifically, we document and analyze the ways that users extend the function of hashtagging beyond findability toward meta-communication, effectively(More)
Since 1945, over $4.9 trillion dollars of international aid has been allocated to developing countries. To date, there have been no estimates of the regional impact of this aid on the carbon cycle. We apply a geographically explicit matching method to estimate the relative impact of large-scale World Bank projects implemented between 2000 and 2010 on(More)
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