Serpil Nebioğlu

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The Ca(2+)-ATPase activity of rat brain microsomes was studied in streptozotocin (STZ)-induced diabetes. Male rats, 200-250 g, were rendered diabetic by injection of STZ (45 mg kg(-1) body weight) via the teil vein. Brain tissues were collected at 1, 4 and 10 weeks after diabetes was induced for determination of Ca(2+)-ATPase activity, lipid peroxidation(More)
In the present study, we assessed oxidative stress in patients with dilated cardiomyopathy of ischemic or idiopathic etiology. For this reason we measured whole blood reduced glutathione, erythrocyte superoxide dismutase, susceptibility of erythrocyte membranes and erythrocytes to peroxidation, and SH content of erythrocyte membranes in 12 patients (8 men(More)
Kidney Ca(2+)-ATPase activity was altered in streptozotocin (STZ)-induced diabetic rats. Male rats, 200-250 g, were rendered diabetic by injection of STZ 45 mg/kg body weight via the tail vein. Following injection, control rats and diabetic rats at 1, 4, 8 or 15 weeks were sacrificed. Kidney tissues were obtained for the isolation of Ca(2+)-ATPase.(More)
The activation of phosphodiesterase by calmodulin isolated from diabetic rat lens tissue was determined. Male rats, 200-250 g, were rendered diabetic by injection of streptozotocin (45 mg/kg body weight) via the tail vein. After the onset of diabetes, the animals were observed for 15 weeks. Compared with a blood glucose level of 94.84 +/- 2.72 mg/dL in the(More)
Renal transplantation is widely used to treat patients with end-stage renal disease. Atherosclerosis is an important posttransplantation risk factor for renal transplant recipients. Subsequent to transplantation low-density lipoprotein (LDL) particles become susceptible to oxidative modification, which results in atherosclerosis. Therefore, the aim of our(More)
The heart cannot supply sufficient blood for tissue metabolic needs in patients with congestive heart failure. Hypoxia and organ hypoperfusion increase oxidative activity. It has been reported that free radicals are involved in the genesis of heart failure. The aim of this study was to assess the status of oxidative stress by simple measurements in patients(More)
Fifty volunteers among the students of the Faculty of Pharmacy at Ankara and Gazi Universities were taken 2 grams of Vitamin C per day at regular time intervals for two months. Blood and urine samples were collected in the beginning, one month and 2 months after vitamin administration. The whole blood, plasma and leucocyte ascorbic acid levels were(More)
A group of 50 volunteers of our Faculty students have taken Vitamin C 2 g per day at regular time intervals for 2 months. Blood samples were taken in the beginning, one month and 2 months after vitamin administration. Cholesterol, HDL-cholesterol, lipoprotein and triglyceride concentrations were determined. Cholesterol concentrations were decreased(More)
Microsomal Ca2+-ATPase activity was studied in control and streptozotocin (STZ)-induced diabetic rat livers. Male rats were rendered diabetic by injection of STZ (45 mg/kg body weight) via the tail vein. Diabetic rats at 1, 4, 8, 10 or 15 wk and control rats were sacrificed. Liver tissues were obtained for the isolation of Ca2+-ATPase. Ca2+-ATPase activity(More)
Rats trained on a diurnal controlled meal-feeding schedule and injected with a single dose of 3,5,3'-triiodothyronine (T3) failed to accumulate liver glycogen and incorporated less D-[6-3H]glucose into glycogen than normally observed during the feeding period. In the experimental group, the concentration of liver adenosine 3',5'-cyclic monophosphate (cAMP)(More)