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Most colorectal cancers have loss of function mutations in the adenomatosis polyposis coli (APC) tumor suppressor gene. This leads to accumulation of beta-catenin, which together with the DNA binding protein TCF-4 functions as a transcriptional activator. Recently defined target genes are c-myc and cyclin D1, linking the APC gene defect to the capacity for(More)
beta-catenin was shown to be a major oncoprotein in colon cancer development. Its oncogenic function as a transcriptional activator is upregulated by mutations in the APC tumor suppressor gene, leading to a constitutive activation of the proliferation-associated genes c-myc and cyclin D. The aim of this study was to demonstrate a role of APC-mutations and(More)
D. Alloyeau,1,*,† B. Freitag,2 S. Dag,3 Lin W. Wang,3 and C. Kisielowski1,*,‡ 1National Center for Electron Microscopy, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA 2FEI Company, Eindhoven, Building AAE, Achtseweg Noord 5, P.O. Box 80066, 5600 KA Eindhoven, The Netherlands 3Scientific Computing Group, Computational Research(More)
THE ONCOPROTEIN B-CATENIN ACTIVATES THE EXPRESSION OF THE INVASION FACTOR MMP-7 IN HUMAN COLORECTAL CANCER Th Brabletz, A Jung, S Dag, T Kirchner Pathologisches Institut, Universitiit Erlangen Objective: Mutations in the tumor suppressor gene APC lead to a constitutive activity of the transcriptional activator B-catenin/TCF4 in colorectal cancer. Recently(More)
In this study, fracture analysis of a fibrous composite laminate with variable fiber spacing is carried out using Jk-integral method. The laminate is assumed to be under thermal loading. Jk-integral is formulated by using the constitutive relations of plane orthotropic thermoelasticity. Developed domain independent form of the Jk-integral is then integrated(More)
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