Sergio Yoshi

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OBJECTIVE A challenging issue is to create a heart valve with growth and remodeling potential, which would be of great interest for congenital heart valve surgery. This study was performed to evaluate the growth and remodeling potentials of a decellularized heart valve. METHODS In 4 juvenile sheep (age 12 +/- 1 weeks) with a weight of 24.3 +/- 4.4 kg, a(More)
BACKGROUND AND AIM OF THE STUDY A new-generation heart valve was developed to improve long-term durability. The study aim was to evaluate the need for in-vitro autologous endothelial cell seeding of a decellularized valve scaffold. METHODS A seeded (group I, n = 6) or non-seeded (group II, n=6) decellularized valve was implanted into the right ventricular(More)
OBJECTIVE This study was performed to evaluate the possibility of creating a glutaraldehyde-free porcine xenograft to improve long-term durability. METHODS A decellularized porcine pulmonary valve was implanted into the right ventricular outflow tract of 7 juvenile sheep. Valves were explanted after 3 months (n = 4) and 6 months (n = 3). Evaluation was(More)
Surface antigens of HeLaHVJ cells, a cell line persistently infected with HVJ, were studied by fluorescent antibody staining. After absorption with concentrated HVJ virions and HeLa cells, anti-HeLaHVJ antiserum was able to demonstrate specific surface fluorescence on HeLaHVJ cells, while this serum no longer reacted with original HeLa cells nor with HVJ(More)
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