Sergio Roberto Sobrino-Cossío

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PURPOSE The aims of this study are to characterize the frequency, density, and distribution of aberrant crypt foci (ACF) and its histological features and to determine the frequency of loss of expression of DNA mismatch repair (MMR) proteins of subjects with hereditary nonpolyposic colorectal cancer (HNPCC) and sporadic colon rectal cancer (CRC). METHODS(More)
BACKGROUND chronic radiation proctopathy (CRP) is associated with recurrent rectal bleeding and transfusional requirements. Argon plasma coagulation (APC) and hyperbaric oxygen therapy (HOT) have been shown to be effective in the control of CRP. No prospective comparisons have been reported between these treatments. AIM the aim was to evaluate the(More)
BACKGROUND/AIMS To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms. METHODS Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other(More)
BACKGROUND/AIMS Gastroesophageal reflux disease is a highly prevalent disease. Assessing treatment efficacy is critical in that clinical endpoints are properly evaluated. Clinical tools for symptoms severity assessment should be discriminative, predictive and evaluative. METHODS In this study we compared a patient-oriented symptoms evaluation (ReQuest™)(More)
OBJECTIVES:During an endoscopic variceal ligation, we banded a varix with an overlying tongue of Barrett's epithelium (BE). One month later, the tongue was no longer visible, suggesting that banding could be used to eradicate BE.AIM:To assess the safety and efficacy of banding without resection (BWR) using a variceal banding device for eradicating(More)
BACKGROUND To improve proton pump inhibitor effects, pharmacological modifications have been developed such as the use of enantiomer molecules (e.g., S-omeprazole, S-pantoprazole, or dexlansoprazole), or addition of NaHCO3 (for an immediate release) or magnesium (with a lower absorption for a more sustained effect). OBJECTIVE The objective of this study(More)
BACKGROUND gastric cancer patients are first diagnosed with an unresectable tumor in up to 40% of cases. Gastric outlet obstruction causes nausea, vomiting, dehydration and malnutrition. The aim of the study was to compare self-expanding metal stents to antrectomy and Roux-en Y gastrojejunostomy for palliation of obstructive adenocarcinoma of the gastric(More)
a Research Office, Hospital General de México O.D., Mexico City, Mexico b Department of Endoscopy, Instituto Nacional de Cancerología, Mexico City, Mexico c Medical Biological Research Institute, Universidad Veracruzana, Veracruz, Ver., Mexico d Department of Clinical Studies, Takeda-México, Naucalpan, Edo. Mex., Mexico e Medical Office, Takeda-México,(More)
Juan Carlos Lopez-Alvarenga,* Sergio Sobrino-Cossio, Ronnie Fass and Jose A Vargas-Romero Core of Biostatistics, Clinical Research Department, Hospital General de Mexico, Mexico City, Mexico; Department of Endoscopy, Instituto Nacional de Cancerologia, Mexico City, Mexico; Nycomed Mexico SA de CV, Mexico City, Mexico; Adjunt Scientist, Department of(More)
232 Journal of Neurogastroenterology and Motility G. Autoantibodies in patients with gut motility disorders and enteric neuropathy. Scand J Gastroenterol 2007;42:1289-1293. 6. Takase H, Yamamura E, Murakami Y, Ikeuchi T, Osada Y. Gastrointestinal invasion by herpes simplex virus type 1 inoculated cutaneously into the immunosuppressed mice. Arch Virol(More)