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Although reduced-intensity conditioning (RIC) and non-myeloablative (NMA)-conditioning regimens have been used for over a decade, their relative efficacy vs myeloablative (MA) approaches to allogeneic hematopoietic cell transplantation in patients with AML and myelodysplasia (MDS) is unknown. We compared disease status, donor, graft and recipient… (More)
 Lake sediment pore water has been proposed as a noble gas archive for paleoenvironmental reconstruction, but appropriate experimental techniques have not been available until recently. Here we present noble gas concentrations measured in the sediment pore water of Lake Issyk-Kul (Kyrgyzstan) which demonstrate for the first time the value of the sediment… (More)
Thirty adults with leukemia or lymphoma undergoing marrow transplantation from HLA-compatible unrelated donors received tacrolimus (FK506), a new immunosuppressive macrolide lactone, and minidose methotrexate to prevent acute graft-versus-host disease (GVHD). The group had a median age of 36 years (range 21 to 49 years). Twenty-four patients had advanced… (More)
Marine Isotope Stage 3 (MIS 3, 59.4–27.8 kyr BP) is characterized by the occurrence of rapid millennial-scale climate oscillations known as Dansgaard–Oeschger cycles (DO) and by abrupt cooling events in the North Atlantic known as Heinrich events. Although both the timing and dynamics of these events have been broadly explored in 5 North Atlantic records,… (More)
Relapsed and refractory (rel/ref) mantle cell lymphoma (MCL) portend a dismal prognosis. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only potentially curative therapy in this setting. We analyzed the survival outcomes of 29 recipients of non-myeloablative allo-HSCT for rel/ref MCL, and studied possible prognostic factors in… (More)
Light-chain amyloidosis (AL) is a plasma cell dyscrasia closely related to multiple myeloma. In multiple myeloma, the cancer-testis antigens (CTAs) CT7 (MAGE-C1), CT10 (MAGE-C2) and MAGE-A CTAs are expressed in up to 80% of cases. In this study, we investigated the expression and immunogenicity of several CTAs in patients with AL amyloidosis in a total of… (More)
PURPOSE Standard G-band cytogenetic analysis (CG) provides information on approximately 25 metaphases for monitoring the presence of Philadelphia chromosome positive (Ph+) cells in chronic myelogenous leukemia (CML) patients, making the detection of a low frequency of Ph+ cells problematic. The purpose of this study was to improve the detection of a low… (More)