Sergey Sibiriak

Learn More
The polymorphism at position -308 of the TNF-alpha gene promoter was analyzed in three ethnic groups and in patients with infiltrative pulmonary tuberculosis from Bashkortostan. No interethnic difference in allele or genotype frequency distribution was observed. The frequency of allele TNF2 in tuberculosis patients was significantly higher than in controls(More)
Repeated stress led to antipodal directions in immune system and cytochrome P450 activities of normotensive and hypertensive rats. Enhancement of the Reaction of Delayed Hypersensitivity, suppression of cytochrome P450-mediated monooxigenase activities were observed in Wistar rats. On the contrary, in the NISAG decrease of the Reaction Delayed(More)
We carried out a systematic study of immunotropic activity of John's wort on the level of integrated fractions including all basic active substances of this plant. Both types of substances capable of increasing and suppressing the immunity were found in John's wort. Polyphenol fraction exhibits the immunostimulating activity with respect to the system of(More)
Experiments were conducted on mices to study the effect of strain MRe-600 Escherichia coli endotoxin, rifampicin, and their combination at the level of cytochrome p-450, b5, aminopyrine N-demethylase and aniline-r-hydroxylase activity in the liver, absorptive activity and oxygen dependent metabolism of macrophages, and free-radical processes in the liver.(More)
The authors studied the effect of decoctions and infusions of medicinal plants (common barberry, sandy immortelle, common maize, spotted milk thistle) on free-radical oxidation (FRO) in model systems in vitro and in experiments in vivo on nonbred albino mice. In various model systems (in which active forms of oxygen are generated and lipid peroxidation(More)
Effects of the actoprotector bemithyl (50 mg/kg, p.o.) upon a single or five-fold administration on the cytochrome P-450 and b5 content and the isoform-specific and nonspecific monooxygenase activity [aminopyrine-N-demethylase, aniline-p-hydroxylase, 4-nitroanisole-o-demethylase,2,5-diphenyloxazole-p-hydroxylase, 7-ethoxyresorufin-o-deethylase (EROD),(More)
The effect of different immunostimulants (prodigiosan, levamisole, T-activin, sodium diethyl dithiocarbamate, sodium nucleinate, lithium chloride, muramil dipeptide, B-activin) and mixed hepatic function oxidase inhibitors (cimetidine, chloramphenicol) or inducers (phenobarbital, flumecinol, rifampicin) on immune reactivity (macrophage function, humoral and(More)
In experiments on white male mice it was found that an immunostimulant prodigiozan suppresses the activity of cytochrome P-450-dependent liver monohygenases that results in modulation of the activity of neuroleptics (aminazine and haloperidol) administered against its background. Their activity is assessed by the "open field "test" and the "tail suspension(More)
Effects of levamisole and prodigizan on the development of adjuvant arthritis, the level of circulating immune complexes (CIC) and spontaneous stimulation of adjacent lymph nodes were studied on 150 noninbred rats. Administration of levamisole in a dose of 2.5 mg/kg bw daily from the first to the 12th day after injection of complete Freund's adjuvant(More)
During a comparative analysis of efficacy of prodigiosan and its combinations with cyclophosphamide (5 mg/kg), asathioprine (4 and 20 mg/kg) and delagil (25 mg/kg) it was shown that the most pronounced suppression of the adjuvant disease was observed in the group of animals given cyclophosphamide with prodigiosan. The suppression of arthritis with(More)