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In order to elucidate the role of proteins CLV1, CLV2, CLV3, and WUS in the mechanism underlying the maintenance of compartmental structure (spatial arrangement of the zones of biosynthesis of marker proteins) of the shoot apical meristem, a model of such mechanism was developed. Computational experiments led to biologically plausible solutions only when(More)
The effects of central administration of substance P (SP) on alcohol consumption and dopamine metabolism in the projections of the mesocorticolimbic and nigrostriatal systems of the brain were studied in chronically alcoholic rats. Rats received 15% ethanol solution for 6 months without choice. Intraventricular administration of SP (1 microg/rat) decreased(More)
316 The shoot apical meristem (SAM) is a structure that is very important for plant growth [1, 2]. The foll lowing areas are distinguished in SAM [3, 4]. (1) The central zone (CZ) consists of a tapered cell accumulaa tion where six to eight cells are found on SAM surface and one or two cells occur at a depth of three or four cells from the apex. CZ is(More)
The epidermis of a linear leaf, as in Poaceae, is established by parallel files of cells originating from the leaf base. Their feature is symplastic growth where neighboring cell walls adhere and do not slide along each other. We developed a simple mechanical cell-based model for symplastic growth of linear leaf blade. The challenge is to determine what(More)
The experimental data obtained to date has provided grounds for certain concepts of stem cell niche regulation in shoot apical meristem (SAM). Mathematical modeling is used to check their consistency and coherence with the experimental data. In this paper, we summarize mathematical models of stem cell niche structure regulation proposed by different(More)
Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly (p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic activity was not inferior to the(More)
We studied cerebroprotective properties of neuropeptide cycloprolylglycine (1 mg/kg) administered intraperitoneally to rats with modeled incomplete global ischemia rats and neuroprotective properties for HT-22 cells under conditions of glutamate toxicity. It was shown that the neuropeptide administered during the postischemic period restored the(More)
Understanding the principles and mechanisms of cell growth coordination in plant tissue remains an outstanding challenge for modern developmental biology. Cell-based modeling is a widely used technique for studying the geometric and topological features of plant tissue morphology during growth. We developed a quasi-one-dimensional model of unidirectional(More)
Effect of noopept (N-phenylacetyl-prolylglycine ethyl ester) on viability of neurons exposed to neurotoxic action of glutamic acid (5 mM) was studied in vitro in immortalized mouse hippocampal HT-22 neurons. Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10–11-10–5 M. Comparison of the(More)
Embryo morphodynamics at early developmental stages of Arabidopsis thaliana has been studied. A pipeline has been elaborated from confocal microscopy and tissue 3D reconstruction to cell-lineage tracing and numerical simulation of growing embryo mechanics. Tentative results of its use are presented.