Sergey M. Korogod

Leonid P Savtchenko2
Alexej N Verkhratsky1
Darya V Kiryushko1
Nikolaj Kulahin1
2Leonid P Savtchenko
1Alexej N Verkhratsky
1Darya V Kiryushko
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Rapid activation of synaptic receptor-channels evokes an ion current that flows through the narrow synaptic cleft; this exerts a significant voltage drop and therefore strong electric field (10(4) V/m range) directed towards the current sinks in the cleft. To what extent this field affects fast diffusion of charged neurotransmitter molecules is not known.(More)
We propose a mathematical model for calcium dynamics ([Ca2+]i) during metabotropic activation of a specialized astrocyte, the cerebellar Bergmann glial cell. The model adequately describes the experimentally observed behaviour of the prototype in response to single and repetitive metabotropic stimuli and to the inhibition of Ca2+ uptake into the store. By(More)
The impact of dendritic geometry on somatopetal transfer of the current generated by steady uniform activation of excitatory synaptic conductance distributed over passive, or active (Hodgkin-Huxley type), dendrites was studied in simulated neurons. Such tonic activation was delivered to the uniform dendrite and to the dendrites with symmetric or asymmetric(More)
The complex and diverse geometry of neuronal dendrites determines the different morphological types of neurons and influences the generation of complex and diverse discharge patterns at the cell output. The recent finding that each temporal pattern has its spatial signature in the form of a combination of high- and low-depolarization states of asymmetrical(More)
Geometry and membrane properties of the dendrites crucially determine input-output relations in neurons. Unlike geometry often available in detail from computer reconstruction, the membrane resistivity is fragmentarily known if at all. Moreover, it varies during ongoing activity. In this study we address the question: what is the impact of the variation in(More)
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