Sergey M. Korogod

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Following reconstruction with high spatial resolution of the 3-D geometry of the dendritic arborizations of two abducens motoneurons, we simulated the distribution of electronic voltage over the whole dendritic tree. Here, we demonstrate that the complex stochastic electronic structure of both motoneurons can be reduced to a statistically significant small(More)
A neuron in vivo receives a continuous bombardment of synaptic inputs that modify the integrative properties of dendritic arborizations by changing the specific membrane resistance (R(m)). To address the mechanisms by which the synaptic background activity transforms the charge transfer effectiveness (T(x)) of a dendritic arborization, the authors simulated(More)
Recent experimental findings (Yuste R. and Denk W. (1995) Nature 375, 682-684) suggest that dendritic spines possess excitable membranes. Theoretically, it was shown earlier that the shape of active spines can significantly affect somatopetal synaptic signal transfer. Studies of long-term potentiation in the hippocampus have related the increased synaptic(More)
We describe how the stochastic geometry of dendritic arborization of a single identified motoneuron of the rat affects the local details of its electrotonic structure. After describing the 3D dendritic geometry at high spatial resolution, we simulate the distribution of voltage gradients along dendritic branches under steady-state and transient conditions.(More)
Ultrastructural studies on the synaptology of dendritic arborizations of motoneurones have been problematic because dendrites are very thin in relation to their great length, and most of the studies on this topic have therefore dealt with only small parts of the dendritic tree. Here we compared the ultrastructural characteristics of the axon terminals(More)
The functional geometry of the reconstructed dendritic arborization of Purkinje neurons is the object of this work. The combined effects of the local geometry of the dendritic branches and of the membrane mechanisms are computed in passive configuration to obtain the electrotonic structure of the arborization. Steady-currents applied to the soma and(More)
The impact of dendritic geometry on somatopetal transfer of the current generated by steady uniform activation of excitatory synaptic conductance distributed over passive, or active (Hodgkin-Huxley type), dendrites was studied in simulated neurons. Such tonic activation was delivered to the uniform dendrite and to the dendrites with symmetric or asymmetric(More)
For technical, instrumental and operator-related reasons, three-dimensional (3D) reconstructions of neurons obtained from intracellularly stained neuronal pieces scattered in serial sections are blurred by some morphological noise. This noise may strongly invalidate conclusions drawn from models built using the 3D reconstructions and it must be taken into(More)
The relationships between somatofugal electronic voltage spread, somatopetal charge transfer and non-uniform geometry of the neuronal dendrites were studied on the basis of the linear cable theory. It is demonstrated that for the dendritic arborization of arbitrary geometry, the path distribution of the relative effectiveness of somatopetal synaptic charge(More)
Topographical maps of membrane voltages were obtained during action potentials by imaging, at 1 microm resolution, live dissociated neurons stained with the voltage sensitive dye RH237. We demonstrate with a theoretical approach that the spatial patterns in the images result from the distribution of net positive charges condensed in the inner sites of the(More)