Sergey L. Kuznetsov

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HERG potassium channels have a critical role in the normal electrical activity of the heart. The blockade of hERG channels in heart cells can result in a potentially fatal disorder called long QT syndrome. HERG channels can be blocked by compounds with diverse structures belonging to several drug classes. Presented herein are generative (Generative(More)
This study concerns large margin nearest neighbors classifier and its multi-metric extension as the efficient approaches for metric learning which aimed to learn an appropriate distance/similarity function for considered case studies. In recent years, many studies in data mining and pattern recognition have demonstrated that a learned metric can(More)
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We report a multilens X-ray interferometer consisting of six parallel arrays of planar compound refractive lenses, each of which creates a diffraction limited beam under coherent illumination. Overlapping such coherent beams produces an interference pattern demonstrating substantially strong longitudinal functional dependence. The interference fringe(More)
We report a novel hard x-ray interferometer consisting of two parallel channels manufactured in a single Si crystal by means of microfabrication technology. The sidewall surfaces of the channels, similar to mirrors, scatter at very small incident angles, acting equivalently to narrow micrometer size slits as in the Young double-slit interferometer.(More)
We present results of RXTE observations of the X-ray source Cyg X-2 during 1996–1999. Its power density spectra in the 0.1–128-Hz band are fitted by a model that takes into account the power-law spectral behavior at frequencies below and above the break frequency, with an introduction of one or more Lorenz lines to describe the peaks of quasi-periodic(More)
We report a novel type of x-ray interferometer employing a bilens system consisting of two parallel compound refractive lenses, each of which creates a diffraction limited beam under coherent illumination. By closely overlapping such coherent beams, an interference field with a fringe spacing ranging from tens of nanometers to tens of micrometers is(More)
An efficient and compact scheme for diode-pumped Nd:YLF laser wavelength conversion to 943 nm was demonstrated by use of difference-frequency mixing and stimulated Raman scattering. We believe that this is the highest conversion efficiency from the laser fundamental wavelength reported to date. It is shown that RbTiOPO4 crystals are capable of providing(More)
Motivated by assessing the aeroelastic stability of a conveyor solution, the aeroelastic stability of a U-beam with an aspect ratio (width B over frontal height H) of B/H = 4.62 is investigated. Wind-tunnel experiments involving a special test stand for sectional models and complementary CFD simulations were carried out. We find that the U-beam can perform(More)
The RXTE observations of Scorpius X-1 in 1996–1999 are presented. The properties of its quasi-periodic Xray oscillations are studied in detail. The results obtained are used for analysis in terms of the transition-layer model (TLM) and the relativistic-precession model (RPM) for a slowly rotating neutron star. Theoretical predictions of the two models are(More)