Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Digestive vacuole membrane in Plasmodium falciparum-infected erythrocytes: relevance to templated nucleation of hemozoin.

• Sergey Kapishnikov, Allon Weiner, Eyal Shimoni, Gerd Schneider, Michael Elbaum, Leslie Leiserowitz
• Langmuir : the ACS journal of surfaces and…
• 2013

Crystallization of the malaria pigment hemozoin sequesters the toxic heme byproduct of hemoglobin digestion in Plasmodium -infected red blood cells (RBCs). Recently, we applied electron and X-ray… (More)

Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum.

• Sergey Kapishnikov, Allon Weiner, +6 authors Michael Elbaum
• Proceedings of the National Academy of Sciences…
• 2012

Heme detoxification is a critical step in the life cycle of malaria-causing parasites, achieved by crystallization into physiologically insoluble hemozoin. The mode of nucleation has profound… (More)

Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction.

• Sergey Kapishnikov, Trine Berthing, +5 authors Leslie Leiserowitz
• Proceedings of the National Academy of Sciences…
• 2012

The human malaria parasite Plasmodium falciparum detoxifies the heme byproduct of hemoglobin digestion in infected red blood cells by sequestration into submicron-sized hemozoin crystals. The crystal… (More)

Development of Correlative Cryo-soft X-ray Tomography and Stochastic Reconstruction Microscopy. A Study of Cholesterol Crystal Early Formation in Cells.

• Neta Varsano, Tali Dadosh, +6 authors Lia Addadi
• Journal of the American Chemical Society
• 2016

We have developed a high resolution correlative method involving cryo-soft X-ray tomography (cryo-SXT) and stochastic optical reconstruction microscopy (STORM), which provides information in three… (More)

Biochemistry of malaria parasite infected red blood cells by X-ray microscopy

• Sergey Kapishnikov, Leslie Leiserowitz, +5 authors Jens Als-Nielsen
• Scientific Reports
• 2017

Red blood cells infected by the malaria parasite Plasmodium falciparum are correlatively imaged by tomography using soft X-rays as well as by scanning hard nano-X-ray beam to obtain fluorescence maps… (More)

Laser-induced aligned self-assembly on water surfaces.

• Iftach Nevo, Sergey Kapishnikov, +7 authors Leslie Leiserowitz
• The Journal of chemical physics
• 2009

The key to functionalize of engineered molecularly nanometer thick films lies in the ability to reproducibly control their structure. A number of factors influence the film morphology of… (More)

The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance.

• Faustine Dubar, Timothy J Egan, +17 authors Christophe Biot
• ACS chemical biology
• 2011

Inhibition of hemozoin biocrystallization is considered the main mechanism of action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot fully explain the activity of ferroquine… (More)

Vitrification of thick samples for soft X-ray cryo-tomography by high pressure freezing.

• Allon Weiner, Sergey Kapishnikov, +4 authors Michael Elbaum
• Journal of structural biology
• 2013

Soft X-ray cryo-microscopy (cryo-XT) offers an ideal complement to electron cryo-microscopy (cryo-EM). Cryo-XT is applicable to samples more than an order of magnitude thicker than cryo-EM, albeit at… (More)

Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography

• Sergey Kapishnikov, Daniel Grolimund, +4 authors Leslie Leiserowitz
• Scientific Reports
• 2017

A key drug target for malaria has been the detoxification pathway of the iron-containing molecule heme, which is the toxic byproduct of hemoglobin digestion. The cornerstone of heme detoxification is… (More)

• ‹
• 1
• ›