Sergey Golovko

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Gamma aminobutyric acid (GABA) is one of the main inhibitory neurotransmitters in the mammalian brain. Its effects are realized via GABA(A), GABA(B), and GABA(C) receptors. GABA(A) is the most abundant type of GABA receptors. It consists of six classes of subunits, alpha, beta, gamma, delta, epsilon, and chi. Acute and chronic exposures to ethanol are(More)
Morphometrical parameters, osmoregulatory possibilities, and the value of membrane reserve of nucleated hemocytes (leukocytes and erythrocytes) of the main vertebrate animal classes were studied with use of the method of hypoosmotic loadings. It has been established that in erythrocytes, in the fish—mammal row, the absolute reserve of plasmalemma increases,(More)
A growing bulk of experimental data indicates that change of certain neurotransmitter receptors and voltage-dependent ion cannels are characteristic manifestations accompanying ethanol consumption. A likely target for ethanol effects is the glutamate receptors. Glutamate is one of major excitatory neurotransmitter in the mammalian brain. While the acute(More)
Naltrexone and naloxone, being competitive antagonists of opioid receptors, have found therapeutic applications in medicine. The experiments with mutant receptors showed that many amino acid residues within transmembrane domains play an important role in binding these drugs. Using the site-directed mutagenesis technique, it was established that even single(More)
Ultra rapid opioid detoxification (UROD) is a new technique with the use of mu-opioid receptor antagonists to precipitate withdrawal. The scientific literature on UROD techniques in opiate addicts are reviewed, but little has been published on its neurochemical aspects. It is discussed that exposure to naloxone ore naltrexone during UROD is associated with(More)
The aim of this study was to determine whether the Pictogram Test (PT; Vygostsky, 1960) a test of logical memory that was developed in Russia, is applicable for diagnosing and understanding thought disturbances in schizophrenia within an English-speaking population. Participants included 62 patients with schizophrenia or schizoaffective disorders and 80(More)
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