Sergey G Kuznetsov

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Apoptosis plays an important role in immunity and is widely used to eliminate foreign or infected cells. Cnidaria are the most basal eumetazoans and have no specialised immune cells, but some colonial cnidarians possess a genetic system to discriminate between self and non-self. By grafting epithelia of different species we have previously shown that the(More)
Although Cnidaria have no specialised immune cells, some colonial forms possess a genetic system to discriminate between self and nonself. Allorecognition is thought to protect them from fusion with genetically different individuals and to prevent germ line parasitism. Surprisingly, when grafting tissue of two species of the solitary freshwater polyp Hydra,(More)
The goal of the study was to obtain a panel of monoclonal antibodies (MAb) against antigens of freshwater polyps of the genus Hydra. Hybrid mice F1(Balb/c × SJL/J) were immunized with cell membrane fraction of H. vulgaris and three months later their splenocytes were fused with cultured mouse myeloma cells 653A. Testing of culture fluids in ELISA with(More)
The use in clinical p rac t ice of the previous ly descr ibed hydrochlor ide of 6-[w-(3 ' -phenylpyrrol id ini ' -y l )propionyl ] l ,4 -benzodioxan [2] has been sanctioned by the Ministry of Public Health of the USSR and as a medicinal p repara t ion the compound, (I) , is known as "pyrroxan." It exer t s an adrenal in-block type action and has been found(More)
where A = (CH2)n, n = 4 8; B = (CH2),~, m = 4 12; Ar = Ph, o-MeOC6H4, hetaryl, etc.; R l, R 2 = H or Me (in various combinations) [1]. These compounds significantly differ by their structures from conventional cbolinolytics representing modified (e.g., "loaded" by introducing additional bulky substituents) acetylcholine or its agonists. Nevertheless,(More)
Investigation of the properties of cholinolytics belonging to different structural groups showed that compounds having a cycloalkyl substituent at the carbinol carbon atom exhibit higher activity and lower toxicity than their diaryl analogs [1]. In the previous communications we have described several amino butynols [2, 3] and amino pentynols [4] containing(More)
8. M. V. Korablev and P. I. Lukienko, Antihypoxic Agents [in Russian], Minsk (1976), p. 365. O. V. Toistikova and A. G. Tolstikov, Summaries of Lectures of the VII-th Republican Conference of Young Scientists [in Russian], Tallin (1987), p. 144. O. V. Tolstikova, A. G. Tolstikov, V. S. Shmakov, et al., Summaries of Lectures at the XVII All-Union Conference(More)