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Formation of catalytically active RNA structures within the spliceosome requires the assistance of proteins. However, little is known about the number and nature of proteins needed to establish and maintain the spliceosome's active site. Here we affinity-purified human spliceosomal C complexes and show that they catalyse exon ligation in the absence of(More)
Serine/arginine-rich (SR) proteins are important players in RNA metabolism and are extensively phosphorylated at serine residues in RS repeats. Here, we show that phosphorylation switches the RS domain of the serine/arginine-rich splicing factor 1 from a fully disordered state to a partially rigidified arch-like structure. Nuclear magnetic resonance(More)
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Anthropometric examinations of 31 patients with bilateral incomplete clefts of the upper lip revealed an excessive elongation of the lateral fragments and reduced height of the central part of cleft lip. Two methods of primary rhinocheiloplasty are suggested, depending on the degree of prolabium underdevelopment, both of them permitting levelling of the(More)
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