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All metazoan animals comprise a body plan of different complexity. Since--especially based on molecular and cell biological data--it is well established that all metazoan phyla, including the Porifera (sponges), evolved from a common ancestor the search for common, basic principles of pattern formation (body plan) in all phyla began. Common to all metazoan(More)
The skeletal elements (spicules) of the demosponge Lubomirskia baicalensis were analyzed; they are composed of amorphous, non-crystalline silica, and contain in a central axial canal the axial filament which consists of the enzyme silicatein. The axial filament, that orients the spicule in its longitudinal axis exists also in the center of the spines which(More)
19 Tickkborne encephalitis is one of the most comm mon and dangerous natural focal viral infections in the forest area of Eurasia [1, 2]. The problem of early therr apy for tickkborne encephalitis has not been solved as yet. The specific immunoglobulin used in clinical practice has several disadvantages [3]. Firstly, the proo duction of human immunoglobulin(More)
46 Sponges, or type Porifera, are the earliest multicell lular invertebrates diverged from a common ancestor of Metazoa about 580–635 million years ago [1, 2]. Sponges are a diverse widespread group of animals that play an important role in aquatic ecosystems as biofill trators and have practical applications in pharmacoll ogy and manufacture of(More)
The apparent dissociation constant (Kd) for specific binding of glucocorticoid receptor (GR) and androgen receptor (AR) to DNA was determined in vivo in Xenopus oocytes. The total nuclear receptor concentration was quantified as specifically retained [(3)H]-hormone in manually isolated oocyte nuclei. DNA was introduced by nuclear microinjection of single(More)
The first metagenomic analysis of the microbiome of the first sample of diseased endemic sponge Lubomirskia baicalensis (Pallas, 1771) from Lake Baikal and the comparison of the results with data published earlier on the microbiome of healthy sponges were carried out. Essential changes in the composition and structure of the microbial community were(More)
The morphological description of morphogenesis accompanying primmorph formation from cell aggregates in the endemic Baikal sponge Lubomirskia baicalensis as well as the description of cell composition of these primmorphs was investigated. Development of small sponges from dissociated cells in L. baicalensis is a stepwise process that can be separated into(More)