Sergej V Nikolaev

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The behavioral and biochemical effects of a new dipeptide mimetic of the GK-2 nerve growth factor (NGF) have been studied on a model of chronic cerebral ischemia induced by permanent common carotid artery occlusion in rats. It is established that subchronic intraperitoneal injections of GK-2 (0.5 mg/kg) 4 h after surgery, followed by seven more injections(More)
In order to elucidate the role of proteins CLV1, CLV2, CLV3, and WUS in the mechanism underlying the maintenance of compartmental structure (spatial arrangement of the zones of biosynthesis of marker proteins) of the shoot apical meristem, a model of such mechanism was developed. Computational experiments led to biologically plausible solutions only when(More)
The experimental data obtained to date has provided grounds for certain concepts of stem cell niche regulation in shoot apical meristem (SAM). Mathematical modeling is used to check their consistency and coherence with the experimental data. In this paper, we summarize mathematical models of stem cell niche structure regulation proposed by different(More)
A total synthesis of 8α analogues of steroid estrogens with fluorine in position 2 was achieved. Structural features of these compounds were studied by the example of 17β-acetoxy-2-fluoro-3-methoxy-8α-estra-1,3,5(10)-triene. It was shown that the 8α analogues of 2-fluorosubstituted steroid estrogens have a low uterotropic activity and retain the(More)
The complete absolute configuration of hormaomycin 1 a has been established by HPLC and HPLC/MS experiments with appropriately derivatized 4-propylprolines, (2S,4S)-6 and (2R,4R)-6, as well as 4-(Z)-propenylprolines, cis-5 and trans-5, and also feeding experiments with enantiomerically pure samples of the deuterium-labeled 3-(2'-nitrocyclopropyl)alanine,(More)
316 The shoot apical meristem (SAM) is a structure that is very important for plant growth [1, 2]. The fol lowing areas are distinguished in SAM [3, 4]. (1) The central zone (CZ) consists of a tapered cell accumula tion where six to eight cells are found on SAM surface and one or two cells occur at a depth of three or four cells from the apex. CZ is formed(More)
The effects of central administration of substance P (SP) on alcohol consumption and dopamine metabolism in the projections of the mesocorticolimbic and nigrostriatal systems of the brain were studied in chronically alcoholic rats. Rats received 15% ethanol solution for 6 months without choice. Intraventricular administration of SP (1 μg/rat) decreased(More)
Human nerve growth factor (NGF) mimetic hexamethylenediamide bis-N-monosuccinyl-glicyl-lysine) (GK-2(h)) demonstrates protective activity on immortalized mouse hippocampal cell line HT22 in a concentration up to 10(-13)M against hydrogen peroxide toxicity and in concentration up to 10(-8) M against glutamate toxicity. GK-2(h) dipeptide protects rat PC-12(More)
At the presen t time, the possibil i ty has been shown of using highly active analogs of luliberin in clinical medicine. At the same time, traditional methods of obtaining such preparat ions by combining the mos t effective modifications [ 1] do not always lead to the desirSd result . We have considered some new direct ions in the synthesis of these(More)
Embryo morphodynamics at early developmental stages of Arabidopsis thaliana has been studied. A pipeline has been elaborated from confocal microscopy and tissue 3D reconstruction to cell-lineage tracing and numerical simulation of growing embryo mechanics. Tentative results of its use are presented.