Sergei V Vinogradov

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32-bp inactivating deletion in the beta-chemokine receptor 5 (CCR5) gene, common in Nothern European populations, is associated with reduced HIV-1 transmission risk and delayed disease progression. We have studied the deletion distribution in many populations in Eurasia by polymerase chain reaction analysis of 531 DNA samples representing West and East(More)
PURPOSE The amphiphilic block copolymer Pluronic P85 (P85) increases the permeability of the blood-brain barrier (BBB) with respect to a broad spectrum of drugs by inhibiting the drug efflux transporter, P-glycoprotein (Pgp). In this regard, P85 serves as a promising component for CNS drug delivery systems. To assess the possible effects of P85 on other(More)
The paper outlines some experience in rehabilitating 1250 patients with coronary heart disease (CHD) undergone aortocoronary bypass surgery (ACBS). Rehabilitative measures promoted more rapid and maximally full recovery of physical fitness and cardiorespiratory parameters. The recommended groups of physical activity allow one to differentially approach to(More)
In spite of the fact that clinical condition in 85.6% of coronary patients subjected to aortocoronary shunting has improved against their preoperative status, only 43.3% of them resume work. Invalidity in these patients increases two-fold mounting to 94.4%. The causes of the discrepancy between the expected and real performance are scrutinized with due(More)
A comparison was made of the clinicofunctional efficiency and social significance of surgical therapy techniques in patients with coronary heart disease (CHD). One hundred and seventy eight patients aged 25 to 59 years who had been operated on in the A. N. Bakulev Institute of Cardiovascular Surgery from 1984 to 1987 were examined. In prolonged periods(More)
The experimental and clinical data on different aspects of vitamin and hormone relationships have been summarized in the form of a general concept of the noncoenzymatic thiamine effect, on the basis of a number of premises: (1) discovery of tissue factors limiting the manifestation of the specific activity of administered thiamine (the presence of a tissue(More)
Comparative assessment of posthumous and intravital methods of morphometric study of the pelvis in adult persons was performed in 110 embalmed anatomical specimens and in 81 patient. It was proved statistically, that magnetic resonance tomography and spiral computer tomography (SCT), performed following definite algorithm, appear to be highly informative(More)