Sergei V Shirshev

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We studied isolated and combined effects of leptin and ghrelin on the formation of ILproducing and T-regulatory cells. Leptin in concentrations comparable with its normal blood concentration during pregnancy (trimester II-III) promotes differentiation of peripheral blood CD4+ cells to IL-17-producing cells and enhances IL-17A production, but suppresses the(More)
Effects of chorionic gonadotropin (CG), estradiol, progesterone, and their physiological combinations on apoptosis of human peripheral blood T-lymphocytes were studied. Neither the hormones separately nor their combinations affected the spontaneous apoptosis of T-cells. On stimulation with mitogens, a high dose of CG (100 IU/ml) significantly increased(More)
The effects of chorionic gonadotropin, a basic hormone of pregnancy, on the differentiation of the human thymocytes were studied. The hormone does not affect the phenotype as determined by expression of the membrane molecules CD3, CD4, CD8 and functional activity of intrathymic pre-T-lymphocytes, but stimulates production of autocrine growth factors by(More)
The existence of alphabetaT-lymphocyte differentiation processes have been demonstrated in mouse peripheral lymphoid organs during pregnancy. Study of pregnant Swiss mice has shown that the development of the second half of gestation is accompanied by expression of RAG-1 recombinase mRNA and unrearranged TCR alpha-chain (pre-TCRalpha) preferentially in(More)
Leptin is a peptide hormone synthesized by adipocytes. The main function of leptin is associated with regulation of the body energetic balance and restriction of excess accumulation of fat. This review considers in detail the involvement of leptin in regulation of fundamental effector functions of mononuclear phagocytes, which express receptors for this(More)
The molecular mechanisms of immunomodulatory effects of the major reproductive hormones (human chorionic gonadotropin, leptin, ghrelin, progesterone, estriol, estradiol) underlying the formation of maternal tolerance to semiallogeneic fetus in different trimesters of human pregnancy are reviewed. New data on the effect of hormonal ensembles and(More)
343 In the context of immunology, pregnancy is a phys iological state of tolerance of the immune system of the maternal body to a genetically foreign fetus [1]. This temporary state of the maternal immune system stems from an increased expansion of regulatory T cells (Treg cells), which are characterized by the ability to suppress proliferation of effector(More)
Individual and combined effects of chorionic gonadotropin (CG), estradiol, and progesterone on the production of IFNψ and IL-4 by human peripheral blood lymphocytes was studied in vitro together with certain intracellular mechanisms underlying the hormonal effects. High CG dose (100 IU/ml) proved to significantly decrease IFNψ level in the T cell culture(More)
171 The peptide hormones leptin and ghrelin are func tional antagonists in the energy and fat metabolisms and have multidirectional immunoregulatory activity [1]. These hormones are important for the gestation processes, control of the implantation, and growth and development of the embryo [1]. During the preg nancy, significant changes in fat and energy(More)
The role of cAMP in the regulation of antigen-dependent differentiation of T cells is discussed with consideration of the molecular mechanisms of cAMP effects. Characteristics of activation signal in various T lymphocyte subpopulations determining differential sensitivity to cAMP are reviewed. Specific attention is given to the involvement of the(More)