Serge Gravel

Learn More
The budding yeast proteins Dma1 and Dma2 are members of the unique FHA-RING domain protein family and are linked to mitotic regulation and septin organization by ill-defined mechanisms. We show that Dma2 has ubiquitin ligase activity, and that septins Shs1 and Cdc11 are likely direct in vivo targets. We further propose that human RNF8, rather than Chfr, is(More)
Methylmalonyl-coA epimerase (MCE) follows propionyl-coA carboxylase and precedes methylmalonyl-coA mutase in the pathway converting propionyl-coA to succinyl-coA. MCE deficiency has previously been described in six patients, one presenting with metabolic acidosis, the others with nonspecific neurological symptoms or asymptomatic. The clinical significance(More)
increasing evidence for the role of histone-modifying enzymes on non-histone substrates, including those in the cytoplasm, has been emerging in recent years. some chromatin-modifying proteins, such as the histone methyl transferase eZH2, compartmentalize to both the nucleus and cytoplasm, whereby eZH2 can methylate histones and actin, respectively. 1(More)
  • 1