Serena F. Carville

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Decreased steadiness of muscle force may be associated with ageing and could be a cause of falls in older people. We studied this in isometric and anisometric quadriceps contractions in healthy young and older people. The older group contained people with and without a history of medically unexplained falls. Forty-four young (aged 18–40 years) and 78 older(More)
Over the years, many have viewed Fibromyalgia syndrome (FMS) as a so-called "functional disorder" and patients have experienced a concomitant lack of interest and legitimacy from the medical profession. The symptoms have not been explained by peripheral mechanisms alone nor by specific central nervous system mechanisms. In this study, we objectively(More)
OBJECTIVE There is vast evidence to support the presence of brain aberrations in patients with fibromyalgia (FM), and it is possible that central plasticity is critical for the transition from acute to chronic pain. The aim of the present study was to investigate the relationship between brain structure and function in patients with FM. METHODS Functional(More)
There are conflicting reports of the effects of hormone replacement therapy (HRT) on strength preservation in postmenopausal women, while any effect on power output has received little attention. Decreased steadiness of force generation has been reported in older muscles and may be related to the hormonal changes associated with the menopause, but the(More)
Risk factors for medically unexplained falls may include reduced muscle power, strength and asymmetry in the lower limbs. Conflicting reports exist about strength and there is little information about power and symmetry. Forty-four healthy young people (29.3 ± 0.6 years), 44 older non-fallers (75.9 ± 0.6 years), and 34 older fallers (76.4 ± 0.8 years) were(More)
BACKGROUND There is evidence for augmented processing of pain and impaired endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved in FM pathology, there is a need for closer investigation of endogenous pain modulation. In the present study, we compared the functional connectivity of the descending pain(More)
OBJECTIVE Mood disturbance is common among patients with fibromyalgia (FM), but the influence of psychological symptoms on pain processing in this disorder is unknown. We undertook the present study to investigate the differential effect of depressive symptoms, anxiety, and catastrophizing on 1) pain symptoms and subjective ratings of general health status(More)
Low back pain is the leading cause of long term disability worldwide. The lifetime incidence of low back pain is 58-84%, and 11% of men and 16% of women have chronic low back pain. Back pain accounts for 7% of GP consultations and results in the loss of 4.1 million working days a year. More than 30% of people still have clinically significant symptoms after(More)
OBJECTIVE Fibromyalgia (FM) comprises many symptoms and features. Consequently, studies on the condition have used a wide variety of outcome measures and assessment instruments. We investigated those outcome measures and instruments in association with the OMERACT (Outcome measures in Rheumatoid Arthritis Clinical Trials) FM Workshop initiative to define(More)