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Monitoring the immune competence of cancer patients to predict outcome
A new era of cancer immunotherapy has brought not only successful cancer vaccines but also immunomodulators, such as those that target checkpoint blockade in order to induce endogenous host immuneExpand
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Biomarker characterization using mass cytometry in a phase 1 trial of urelumab (BMS-663513) in subjects with advanced solid tumors and relapsed/refractory B-cell non-Hodgkin lymphoma.
3017 Background: Anti-CD137 antibody was shown in both murine cancer models and in a first-in-human, phase I trial (Sznol et al., 2008) to increase peripheral activated CD8 T cells and IFN-inducibleExpand
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Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study
Purpose: Immune-based therapy for metastatic breast cancer has had limited success, particularly in molecular subtypes with low somatic mutations rates. Strategies to augment T-cell infiltration ofExpand
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Abstract 919: A genome-wide screen in C. elegans identifies cell non-autonomous suppressors of let-60/RAS mediated oncogenic over-proliferation
Coordinated proliferative signals from the mesenchymal cells play a crucial role in the regulation of proliferation of epithelial cells during normal development, wound healing and several otherExpand
Abstract A042: A predictive nomogram to determine CD137 upregulation on NK cells in patients receiving monoclonal antibody therapy
Monoclonal antibody (mAb) therapy, including rituximab (anti-CD20), trastuzumab (anti-HER2) and cetuximab/panitumumab (anti-EGFR) has changed the natural history of patients with B cell lymphomas,Expand
Long term survivors and immune biomarker analysis of Phase IIa, randomized study of GVAX pancreas and crs-207 immunotherapy in patients with metastatic pancreatic cancer
Meeting abstracts Non-clinical and clinical combination studies with GVAX and live-attenuated, double-deleted (LADD) Listeria monocytogenes strains engineered to express tumor-associated antigensExpand
Visceral fat prediction models according to age and gender
Obesity is the leading risk factor for metabolic syndrome and puts individuals at an increased risk for cardiovascular disease and diabetes. Past studies have shown that visceral adipose tissueExpand