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OBJECTIVES To evaluate the gross morphometric changes and in vitro responses of the corpus cavernosus of rats treated with sildenafil citrate after cavernous neurotomy. METHODS The animals were divided into 3 groups. Group 1 consisted of sham-operated rats (n = 16); group 2 consisted of rats that underwent bilateral cavernous neurotomy (BCN) (n = 16); and(More)
This study describes the relaxant response to acetylcholine, electrical field stimulation and sodium nitroprusside after contraction by phenylephrine (10−5 M) in corpus cavernosum from control and diabetic rats. The response to acetylcholine (10−9–10−3 M) and electrical field stimulation (0.5–64 Hz) is decreased and can be restored by the addition of nitric(More)
AIM It is known that physiopathological changes in diabetes affect the function of the bladder. In this study, we aimed to demonstrate the possible effects of diabetes on the urothelium during this physiopathological process. METHODS Diabetes was induced in rats by tail vein injection of 35 mg/kg streptozotocin. Eight weeks later, intact and denuded(More)
The present study was aimed at investigating the effects of diabetes on the cavernosal smooth muscle relaxations mediated by adenosine and adenosine triphosphate (ATP) in tissues obtained from men and rats. Adenosine- and ATP-induced relaxant responses showed an enhanced sensitivity with an unaltered effectiveness in diabetic men. Adenosine-elicited(More)
Direct and indirect (antiadrenergic) inotropic effects of adenosine in the isolated left atrial preparations from streptozotocin-induced diabetic rats were examined by comparing with those from propylthiouracil-induced hypothyroid rats. Experimental diabetes was induced by a single i.v. injection of streptozotocin (45 mg/kg). Subsets of diabetic rats were(More)
Bladder dysfunction and gastrointestinal disorders are common complications of diabetes mellitus and are attributed in part to peripheral neuropathy. Little is known of the mechanisms responsible for the bladder dysfunction and abnormality of the gastrointestinal tract. The effects of experimental diabetes on responses to adenosine, adenosine(More)
The aim of this study is to determine the early effects of partial outflow obstruction (POO) on the detrusor contractility of diabetic (DM) and non-diabetic rats. A total of 67 adult female Wistar rats with average weight of 214±3.1 g were randomized into five groups as control (n=6), sham operated (n=6), obstructed (n=18), DM (n=19), and DM with(More)
AIMS The purpose of the present study was to investigate functional responses and nitric oxide synthase activity in the corpus cavernosum of young control, middle-aged control and middle-aged non-insulin dependent diabetic rats. METHODS The animal groups were treated with ascorbic acid. RESULTS Acetylcholine-mediated endothelium-dependent relaxation of(More)
Experiments were designed to evaluate the mechanisms of propofol and adenosine in rat atrial muscle. Atria were suspended in the isolated organ bath system for isometric tension recording and response to propofol and adenosine were tested in the absence and presence of glibenclamide, N(G)-nitro-arginine-methyl-ester (l-NAME), tetraethylammonium (TEA) and(More)