Seppo Heinonen

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BACKGROUND Most pertinent studies of inadequate antenatal care concentrate on the risk profile of women booking late or not booking at all to antenatal care. The objective of this study was to assess the outcome of pregnancies when free and easily accessible antenatal care has been either totally lacking or low in number of visits. METHODS This is a(More)
OBJECTIVE To assess pregnancy outcomes in different BMI groups. RESEARCH METHODS AND PROCEDURES We analyzed 25,601 singleton pregnancies from January 1989 to December 2001. Overweight women (prepregnancy BMI = 26 to 29 kg/m2) represented 13.2% (3388) of the cases, and 7.3% (1880) were obese (BMI > or = 30 kg/m2). The data were obtained from(More)
BACKGROUND Normal pregnancy is associated with enhanced vasodilatation because of the increased nitric oxide (NO) production. Because L-homoarginine can act as a substrate for NO production, concentrations of L-homoarginine in normal pregnancy were assessed in the present study to test whether L-homoarginine is associated with endothelial function. (More)
OBJECTIVE To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). DESIGN Retrospective case-control study. SETTING University-based clinic. PATIENT(S) One hundred six nondiabetic women with PCOS and 112 nonhirsute(More)
OBJECTIVE To assess maternal risk profile and pregnancy outcome of women who continued to smoke, reduced smoking to less than five cigarettes per day or did not smoke during pregnancy. METHODS We analyzed a population-based database of 26,414 singleton pregnancies from 1989 to 2001. Odds ratios (ORs) for adverse pregnancy outcomes were obtained from(More)
BACKGROUND Poor ovarian and endometrial responses to gonadotrophin stimulation in assisted reproduction techniques lead to decreased pregnancy rates. The aim of the present study was to test the hypothesis that low-dose aspirin started prior to controlled ovarian stimulation improves ovarian responsiveness, pregnancy rate (PR) and pregnancy outcome. (More)
PURPOSE This study evaluated obstetric and neonatal outcome in a community-based cohort of women with active epilepsy (WWAE) compared with the general pregnant population receiving modern obstetric care. METHODS We reviewed the total population who gave birth between January 1989 and October 2000 at Kuopio University Hospital. Obstetric, demographic, and(More)
OBJECTIVE We wished to determine whether genetic variability in the gene encoding endothelial nitric oxide synthase (eNOS) modifies individual susceptibility to the development of preeclampsia. METHODS The study involved 132 preeclamptic and 113 healthy control pregnant women who were genotyped for the Glu298Asp polymorphism in the eNOS gene. Chi(2)(More)
We determined whether or not genetic variability in the promoter region of the gene encoding plasminogen activator inhibitor-1 (PAI1) contributes to individual differences in susceptibility to the development of preeclampsia. The study involved 133 preeclamptic and 115 healthy control pregnant women who were genotyped for a single-nucleotide(More)
PURPOSE Low birth weight (LBW), preterm births, abnormal placentation, and miscarriages have been associated with prior induced abortions. An incidence-related effect has been suggested. The objective of this study is to assess the effects of prior induced abortions on obstetric risk factors and pregnancy outcome in conditions of free high-standard(More)