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Guards of the great wall: bacterial lysozyme inhibitors.

• Lien Callewaert, Joris M. Van Herreweghe, Lise Vanderkelen, Seppe Leysen, Arnout R. D. Voet, Chris W Michiels
• Trends in microbiology
• 2012

Peptidoglycan is the major structural component of the bacterial cell wall. It provides resistance against turgor and its cleavage by hydrolases such as lysozymes results in bacteriolysis. Most, if… (More)

Structural basis of bacterial defense against g-type lysozyme-based innate immunity

• Seppe Leysen, Lise Vanderkelen, Stephen D Weeks, Chris W Michiels, Sergei V. Strelkov
• Cellular and Molecular Life Sciences
• 2012

Gram-negative bacteria can produce specific proteinaceous inhibitors to defend themselves against the lytic action of host lysozymes. So far, four different lysozyme inhibitor families have been… (More)

Molecular basis of bacterial defense against host lysozymes: X-ray structures of periplasmic lysozyme inhibitors PliI and PliC.

• Seppe Leysen, Joris M. Van Herreweghe, +4 authors Sergei V. Strelkov
• Journal of molecular biology
• 2011

Lysozymes play a key role in the innate immune system of vertebrates and invertebrates by hydrolyzing peptidoglycan, a vital component of the bacterial cell wall. Gram-negative bacteria produce… (More)

The structure of the proteinaceous inhibitor PliI from Aeromonas hydrophila in complex with its target lysozyme.

• Seppe Leysen, Joris M. Van Herreweghe, +5 authors Sergei V. Strelkov
• Acta crystallographica. Section D, Biological…
• 2015

Recent microbiological data have revealed that Gram-negative bacteria are able to protect themselves against the lytic action of host lysozymes by secreting proteinaceous inhibitors. Four distinct… (More)

Structural characterization of the PliG lysozyme inhibitor family.

• Seppe Leysen, Lise Vanderkelen, +4 authors Sergei V. Strelkov
• Journal of structural biology
• 2012

Several Gram-negative bacteria protect themselves against the lytic action of host lysozymes by producing specific proteinaceous inhibitors. So far, four different families of lysozyme inhibitors… (More)

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