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Disease‐specific phenotypes in iPSC‐derived neural stem cells with POLG mutations
These studies are the first that show it is possible to recapitulate the neuronal molecular and biochemical defects associated with POLG mutation in a human stem cell model and provide insight into how mitochondrial dysfunction and mtDNA alterations influence cellular fate determining processes.
A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates
This work adapted protocols for differentiating human pluripotent stem cells to functional human cardiomyocytes in a 96-well microplate format and suggested that this protocol provides an incremental improvement and one that reduces the impact of heterogeneity by increasing inter-experimental replicates.
Metagenome-based analysis of the functional potential of a marine sediment community dominated by ANME-2c
This study has fortified the partnership of ANME-2c and sulfate-reducing bacteria from the Desulfobacteraceae family, and revealed new information about other possible aspects of syntrophy, in addition to the methane oxidation coupled to sulfate reduction, in the Nyegga sediments.
Distinct mitochondrial remodeling during early cardiomyocyte development in a human-based stem cell model
It is found that differentiated cardiomyocytes have significantly lower level of mitochondria content compared to their original source, pluripotent stem cells, although the efficiency of ATP generation via mitochondria respiration increases.
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
It is found that mitochondrial content decreases continuously during mesoderm differentiation, despite increased mitochondrial activity and higher levels of ATP-linked respiration, and it is erroneous to assume that increased OXPHOS activity during differentiation requires a simultaneous expansion of mitochondrial content.