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Adipocyte hyperplasia and hypertrophy in obesity can lead to many changes in adipose tissue, such as hypoxia, metabolic dysregulation, and enhanced secretion of cytokines. In this study, hypoxia increased the expression of Wnt10b in both human and mouse adipogenic cells, but not in hypoxia-inducible factor (HIF)-2α-deficient adipogenic cells. Chromatin(More)
Gradient poly(2-hydroxyethyl methacrylate) brushes were synthesized by surface-initiated atom transfer radical polymerization (ATRP) confined within a microfluidic system on a silicon wafer. For ATRP, surface initiator, 11-((2-bromo, 2-methyl) propionyloxy) undecyltrichlorosilane (BUC), was synthesized, and allowed to self-assemble in a monolayer on the Si(More)
This study evaluated HIF-1α inhibitors under different hypoxic conditions, physiological hypoxia (5% O2) and severe hypoxia (0.1% O2). We found that chenodeoxy cholic acid (CDCA) reduced the amount of HIF-1α protein only under physiological hypoxia but not under severe hypoxia without decreasing its mRNA level. By using a proteasome inhibitor MG132 and a(More)
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