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A library of 2'-methoxyethyl-modified antisense oligonucleotides (2'MOE ASO) targeting 1,510 different genes has been developed, validated, and used to identify cell cycle regulatory genes. The most effective molecular target identified was Eg5 (kinesin-like-1), which when inhibited gave the largest increase in 4N DNA in various tumor cells. The Eg5 ASO(More)
[1] Multiple regimes in the atmospheric zonal-mean flow of the Southern Hemisphere are examined using 53 years of daily observational analysis data. Estimates of the probability density function in the reduced-phase space spanned by the two leading empirical orthogonal functions (EOFs) are found to exhibit significant deviations from bivariate Gaussianity.(More)
MicroRNAs (miRNAs) are believed to play important roles in developmental and other cellular processes by hybridizing to complementary target mRNA transcripts. This results in either cleavage of the hybridized transcript or negative regulation of translation. Little is known about the regulation or pattern of miRNA expression. The predicted presence of(More)
Cancers have been described as wounds that do not heal, suggesting that the two share common features. By comparing microarray data from a model of renal regeneration and repair (RRR) with reported gene expression in renal cell carcinoma (RCC), we asked whether those two processes do, in fact, share molecular features and regulatory mechanisms. The majority(More)
Activation of the cell-surface receptor Fas can lead to apoptosis in parenchymal cells in the liver, and if severe enough, result in fulminant hepatic failure and animal death. In the present study, we have examined the roles played by the Bcl-2 family members Bcl-xL and Bid in regulating this response. To do this, we have developed chemically modified(More)
We investigated the use of an antisense oligonucleotide (ASO) specific for mRNA of the alpha chain (CD49d) of mouse VLA-4 to down-regulate VLA-4 expression and alter central nervous system (CNS) inflammation. ISIS 17044 potently and specifically reduced CD49d mRNA and protein in cell lines and in ex-vivo-treated primary mouse T cells. When administered(More)
Zonal-ow v acillation in an idealized two-layer, global, primitive-equation model is studied in the context of multiple regimes. The spatial structure of vertically and zonally averaged zonal-ow v ariability resembles that observed in the Southern Hemisphere, with dipolar anomalies centered at 40 o and 60 o. The probability density function PDF of the(More)
The second track of this year's KDD Cup asked contestants to separate a user's highly rated songs from unrated songs for a large set of Yahoo! Music listeners. We cast this task as a binary classification problem and addressed it utilizing gradient boosted decision trees. We created a set of highly predictive features, each with a clear explanation. These(More)
Multiple regimes in the atmospheric zonal-mean ow of the Southern Hemisphere are examined using 53 years of daily observational analysis data. Estimates of the probability density function in the reduced phase space spanned by t h e t wo leading empirical orthogonal functions EOFs are found to exhibit signiicant deviations from bivariate Gaussianity. Two(More)
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