Seong Hwan Park

Learn More
HuR/Elav-like RNA binding protein 1 (ELAVL1) positively regulates mRNA stability of AU-rich elements (ARE)-containing transcript such as pro-inflammatory cytokines. Ribotoxic stresses can trigger the production of pro-inflammatory mediators by enhancing mRNA stability and the transcriptional activity. We investigated the effects of ribotoxin deoxynivalenol(More)
Pseudomonas fluorescens is an opportunistic indoor pathogen that can cause severe airway proinflammatory responses. Pulmonary epithelium, like other mucosal epithelial linings of the body, constitutes the first line of defense against airway microbial pathogens. Mucosal epithelial cells can be a sentinel of pathogenic bacteria via stimulation of specific(More)
Phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha) is a critical convergence point of the integrated stress response (ISR), which supports eukaryotic cellular adaptation to diverse stressful conditions, including the endoplasmic reticulum (ER) stress by global protein translational arrest and induction of numerous(More)
Ribosome-inactivating stresses possess a potent regulatory activity against tumor cell progression. In this study, we demonstrated that macrophage inhibitory cytokine-1 (MIC-1) and its associated signals determined the colon cancer cell response to the chemical ribotoxic stress. The ribotoxic stress agent anisomycin-induced MIC-1 gene expression which was(More)
Ribotoxic stress responses lead to the expression of genes important for cellular homeostasis by modulating cell survival, proliferation and differentiation. ATF3 was investigated for its modulation of the epithelial cellular integrity in response to mucosal ribotoxic stress. ATF3 expression was up-regulated by chemical agents causing ribotoxic stress such(More)
Chronic exposure to gut bacteria and bacterial products including Nod2 ligands triggers homeostatic regulation in response to various mucosal insults. Activating transcription factor 3 (ATF3) is a negative regulator of proinflammatory cytokines via bacterial pattern recognition. On the assumption that ATF3 can be a critical modulator of epithelial(More)
Type B 8-keto trichothecenes are muco-active mycotoxins that are notable contaminants in cereal-based food stuffs. Epithelial responses are of primary concern during gastrointestinal exposure in human and animal intoxications. Therefore, optimized biomarkers to assess the specific action of trichothecenes on the human epithelial barrier are needed. In the(More)
  • 1