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Ohmyungsamycins A and B: cytotoxic and antimicrobial cyclic peptides produced by Streptomyces sp. from a volcanic island.
A new method utilizing PGME (phenylglycine methyl ester) derivatization coupled with chromatographic analysis to determine the absolute configuration of N,N-dimethylvaline is developed, which will provide a general and convenient analytical method for determining the absolute configurations of amino acids with fully substituted amine groups.
Sungsanpin, a lasso peptide from a deep-sea streptomycete.
Sungsanpin is the first example of a lasso peptide isolated from a marine-derived microorganism and displayed inhibitory activity in a cell invasion assay with the human lung cancer cell line A549.
Borrelidins C–E: New Antibacterial Macrolides from a Saltern-Derived Halophilic Nocardiopsis sp.
Borrelidins C and D displayed inhibitory activity, particularly against the Gram-negative pathogen Salmonella enterica, and moderate cytotoxicity against the SNU638 and K562 carcinoma cell lines.
Salternamide A Suppresses Hypoxia-Induced Accumulation of HIF-1α and Induces Apoptosis in Human Colorectal Cancer Cells
- Duc-Hiep Bach, Seong-Hwan Kim, Ji-Young Hong, H. Park, D. Oh, Sang Kook Lee
- Biology, ChemistryMarine drugs
- 1 November 2015
It is demonstrated that SA efficiently inhibits the hypoxia-induced accumulation of HIF-1α in a time- and concentration-dependent manner in various human cancer cells and is potentially a leading candidate in the development of anticancer agents.
Meroterpenoids from a Tropical Dysidea sp. Sponge.
Six new meroterpenoids (1-6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of…
Gombaspiroketals A-C, sesterterpenes from the sponge Clathria gombawuiensis.
Gombaspiroketals A-C (1-3), tetracyclic sesterterpenes of a novel skeletal class, were isolated from the Korean marine sponge Clathria gombawuiensis and exhibited moderate cytotoxicities and antibacterial activities.
Lajollamycins, nitro group-bearing spiro-β-lactone-γ-lactams obtained from a marine-derived Streptomyces sp.
The lajollamycins exhibited moderate inhibitory activity toward Candida albicans isocitrate lyase and planar structures were elucidated on the basis of spectroscopic analyses by NMR, UV, IR, and MS.
Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva.
The planar structure of tripartin was identified by the spectroscopic analyses of NMR, mass, UV, and IR data, and the absolute configuration of 1 was determined by X-ray crystallography.
Asperphenins A and B, Lipopeptidyl Benzophenones from a Marine-Derived Aspergillus sp. Fungus.
Asperphenins A (1) and B (2), novel diastereomeric lipopeptidyl benzophenone metabolites, were isolated from a marine-derived Aspergillus sp. fungus. On the basis of the results of combined…
Antiviral Indolosesquiterpenoid Xiamycins C-E from a Halophilic Actinomycete.
- Seong-Hwan Kim, T. Ha, W. Oh, Jongheon Shin, D. Oh
- Chemistry, BiologyJournal of natural products
- 22 January 2016
New metabolites, xiamycins C-E (1-3), were isolated from a Streptomyces. sp (#HK18) culture inhabiting the topsoil in a Korean solar saltern. The planar structures of the xiamycins C-E were…