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Mass spectrometry-based metabolite profiling and antioxidant activity of Aloe vera ( Aloe barbadensis Miller) in different growth stages.
TLDR
Analysis of metabolite profiling of four different-sized Aloe vera plants suggested that MS-based metabolomic approaches can illuminate metabolite changes associated with growth and development and can explain their change of antioxidant activity. Expand
Expression and changes of galanin in neurons and microglia in the hippocampus after transient forebrain ischemia in gerbils
TLDR
The results suggest that the early increase of GAL in the CA1 pyramidal cells may be associated with the reduction of the excitotoxic damage, that long-lasting enhanced expression of endogenous GAL at 12 h-2 days after ischemia may be related with efflux of potassium ion into the extracellular space, and that GAL expression in microglia 4 days afterIschemic damage may beassociated with reduction of ischemicdamage. Expand
90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats.
TLDR
A supplemental 90-day oral toxicity study was conducted in Hsd:SD(R) rats to determine the potential of UP446 to produce toxicity and a dose of 1000 mg/kg/day was identified as the NOAEL (no-observed-adverse-effect-level) in this study. Expand
Anti-Obesity Effect of 6,8-Diprenylgenistein, an Isoflavonoid of Cudrania tricuspidata Fruits in High-Fat Diet-Induced Obese Mice
TLDR
The anti-obesity effect of 6,8-diprenylgenistein (DPG), a major isoflavonoid of Cudrania tricuspidata fruits was investigated using high fat-diet-induced obese mice at the doses of 10 and 30 mg/kg for six week and the body weight of the DPG-treated groups was significantly lower compared to the HFD-treated group. Expand
A Comparative Study of Baby Immature and Adult Shoots of Aloe Vera on UVB‐Induced Skin Photoaging in vitro
TLDR
The results suggest that BAE may potentially protect the skin from UVB‐induced damage more than AE, and type I procollagen and TGF‐β1 levels after UVB irradiation. Expand
Comparison of pancreatic lipase inhibitory isoflavonoids from unripe and ripe fruits of Cudrania tricuspidata
TLDR
The maturation stage is an important factor for maximum efficacy and that unripe fruits of C. tricuspidata are a good source of new bioactive constituents for the regulation of obesity. Expand
Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo.
TLDR
Aloesin is found to ameliorates each phase of the wound healing process including inflammation, proliferation and remodeling through MAPK/Rho and Smad signaling pathways and indicates that aloesin has the therapeutic potential for treating cutaneous wounds. Expand
Dihydrolipoyl dehydrogenase as a potential UVB target in skin epidermis; using an integrated approach of label-free quantitative proteomics and targeted metabolite analysis.
TLDR
This study is the first example of an integration of proteomic and metabolite analysis techniques to find new biomarker candidates for the regulation of the UVB-induced skin photoaging, and supports that A. vera exerts significant anti-photodamage activity via regulation of DLD, a novel UVB target, in the epidermis. Expand
Prevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by processed Aloe vera gel.
TLDR
Findings show that PAG suppresses colitis-related colon carcinogenesis by inhibiting both chronic inflammation and cell cycle progression in the colon. Expand
Polysaccharide isolated from Aloe vera gel suppresses ovalbumin-induced food allergy through inhibition of Th2 immunity in mice.
TLDR
It is suggested that processed Aloe vera gel (PAG) containing low molecular weight Aloe polysaccharide (AP) on ovalbumin (OVA)-induced food allergy in mice suppressed Th2 immune responses through, at least partially, stimulating the secretion of IL-10 in food allergy mice. Expand
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