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Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally under street names such as "Spice" and "Smoke". Many countries including Korea have started to schedule some of the JWH series compounds as(More)
Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive. In this study, we examined quetiapine's dependence potential and abuse liability through animal(More)
The aim of the present study was to compare gene expression profiles in animals treated with abusable drugs. Wistar rats were treated with saline, morphine, chloral hydrate, or pentobarbital twice daily for 14 days. To induce neurotoxicity, a group of rats was treated with kainic acid. 24 hr after withdrawal, and a genome-wide DNA microarray analysis was(More)
An artificial implantable lung would be a useful device to support ARDS patients awaiting lung transplantation. In this study, the characteristic of fluid flow in the new type lung assist devices has been established using CFD. According to the modeling, it is believed that the tangential type module would be more beneficial to the fluid flow, and 2 ports(More)
In sports medicine, very little attention has been given to magnesium compared with potassium and calcium. Magnesium ions (Mg<sup>2+</sup>) play a central role of neuronal activity, cardiac excitability, neuromuscular transmission, muscular contraction, vasomotor tone, and blood pressure significantly related to physical performance. Exercise is a potent(More)
The purpose of this study was to investigate the effect of multiple mechanical forces in hemolysis for usage as intravascular lung assist device. Specific attention was focused on the effect of membrane vibration. The results of experimental, PZT materials were used as an exciting system to improve efficiency of blood suitability of hollow fiber membrane(More)
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