Senthil K. Nachimuthu

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To be broadly useful, biomedical terminologies need to capture the knowledge and expertise of multiple experts, research groups and end users. Consequently, the construction of such a terminology requires collaboration among multiple participants. This paper summarizes several terminology projects which employ a collaborative authoring mode in development,(More)
Sepsis is a systemic inflammatory state due to an infection, and is associated with very high mortality and morbidity. Early diagnosis and prompt antibiotic and supportive therapy is associated with improved outcomes. Our objective was to detect the presence of sepsis soon after the patient visits the emergency department. We used Dynamic Bayesian Networks,(More)
Several biomedical vocabularies are often used by clinical applications due to their different domain(s) of coverage, intended use, etc. Mapping them to a reference terminology is essential for inter-systems interoperability. Manual vocabulary mapping is labor-intensive and allows room for inconsistencies. It requires manual searching for synonyms,(More)
Plant-based insecticides for vector control are urgently needed for Anopheles barbirostris, Culex quinquefasciatus, and Aedes albopictus which are the primary vectors of malaria, lymphatic filariasis, and dengue, respectively, in India and other South East Asian countries. In the present study, larvicidal, adulticidal, and repellent activities of acetone(More)
SNOMED CT was created by the merger of SNOMED RT (Reference Terminology) and Read Codes Version 3 (also known as Clinical Terms Version 3). SNOMED CT is considered to be among the most extensive and comprehensive biomedical vocabularies available today. It is considered for use as the Reference Terminology of various institutions. We review the adequacy of(More)
Hybrid text matching algorithms similar to those used for DNA sequencing were developed by 3M Health Information Systems to map a noisy legacy codeset to the 3M Healthcare Data Dictionary (3M HDD). Applying these techniques to map other biomedical vocabularies was briefly introduced in an earlier paper describing the algorithms. We now present results from(More)
In the present study, the near complete mitochondrial genome (mitogenome) of Junonia iphita (Lepidoptera: Nymphalidae: Nymphalinae) was determined to be 14,892 bp. The gene order and orientation are identical to those in other butterfly species. The phylogenetic tree constructed from the whole mitogenomes using the 13 protein coding genes (PCGs) defines the(More)
Plants have been used since ancient times as an important source of biologically active substances. The aim of the present study was to investigate the phytochemical constituents (flavonoids and phenolics), antioxidant potential, cytotoxicity against HepG2 (human hepato carcinoma) cancer cell lines, and the antimicrobial activity of the methanol extract of(More)
Gastric cancer is one of the most common malignancies in India. DNA repair gene or xenobiotic pathway gene polymorphisms have recently been shown to affect individual susceptibility to gastric cancer. Here, the possible interaction between common polymorphisms in X-ray repair cross complementing group I (XRCC1) gene and glutathione S-transferase (GST) genes(More)