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Despite the effectiveness of clomipramine and selective serotonin reuptake inhibitors (SSRIs) in the treatment of obsessive-compulsive disorder (OCD), 40% to 60% of patients who receive an adequate treatment with these agents have significant persisting symptoms. Newer atypical antipsychotic drugs showed efficacy as augmenting agents in patients with OCD(More)
AIM To investigate the relationship between the major depression and bone mineral density (BMD) in premenopausal women. MATERIAL AND METHODS We compared BMD, plasma cortisol level, osteocalcin and C-telopeptide levels of 35 premenopausal women with major depression with those of 30 healthy women who were matched for age and body mass index. Major(More)
The COMT gene has been implicated to be involved in the pathogenesis of obsessive-compulsive disorder (OCD) and various other psychiatric disorders. COMT enzyme activity is governed by a common genetic polymorphism at codon 158 that results in substantial 3- to 4-fold variation in enzymatic activity [a high-activity COMT variant (H) and a low activity(More)
OBJECTIVE Previous studies in Turkey regarding substance use have failed to take into consideration the elementary school students. The purpose of the present study is to determine prevalence of tobacco, alcohol, and substance use among elementary and secondary school students in Turkey. METHOD The study was conducted in 9 big cities that were selected(More)
OBJECTIVE This study aimed to investigate the possible association between T102C and -1438 G/A polymorphism in the 5-HT2A receptor gene and susceptibility to and clinical features of obsessive-compulsive disorder (OCD). METHOD Fifty-eight patients with OCD and 83 healthy controls were included in the study. All patients were interviewed and rated by(More)
OBJECTIVE Our objectives were 1) to determine hemispheric asymmetry and regional differences on the EEGs of patients with obsessive-compulsive disorder (OCD); and 2) to investigate the effects of sex, treatment response, illness duration, and Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores on quantitative electroencephalographic (QEEG) measurements.(More)
OBJECTIVE Replacement of deficient hormones (hormone replacement therapy, HRT) is the main treatment modality in menopause. There is no concensus among researchers as to how HRT influences psychiatric symptoms that might develop during menopausal period. In this study we aimed to explore the effects of HRT on symptoms of anxiety and depression comparatively(More)
Venlafaxine is an effective antidepressant drug that is chemically distinct from other antidepressants. Alprazolam is a triazolobenzodiazepine and diazepam is a 2-ketobenzodiazepine. Benzodiazepines are frequently co-administered with antidepressants, a fact that brings the problem of drug-drug interactions, because they are metabolized by various(More)
The objective of this study was to determine the effects of psychosocial factors such as peer group, family and academic self-perception on smoking, alcohol and substance use by adolescents living in Mersin, Turkey. The study included a total of 3282 students from the sixth and tenth grades and college. The number of participating students required from(More)
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