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Cytotoxic oleanane triterpene saponins from Albizia chinensis.
TLDR
Three new oleanane-type triterpene saponins, albizosides A-C (1-3), were isolated from the stem bark of Albizia chinensis and showed cytotoxic activity against a small panel of human tumor cell lines as well as hemolytic activity against rabbit erythrocytes. Expand
Tumor Necrosis Factor Receptor 2 (TNFR2)·Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-κB Activation*
TLDR
TNFR2 but not TNFR1 forms a heteromer with interleukin-17 receptor D (IL-17RD), also named Sef, to activate NF-κB signaling, which may explain the role of TNFR2 in inflammatory diseases including nephritis. Expand
Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities
TLDR
Hydrangea paniculata extract may protect renal function in LPS-induced AKI by anti-inflammatory and antioxidant activities, and has potential in the critical care of AKI. Expand
Protective effects of icariin on cisplatin-induced acute renal injury in mice.
TLDR
Results indicate that icariin ameliorates the cisplatin-mediated nephrotoxicity via improving renal oxidant status, consequent NF-κB activation and inflammation cascade and apoptosis, and the following disturbed expression of apoptosis related proteins. Expand
The hemi-Mustard, bidirectional Glenn and Rastelli procedures for anatomical repair of congenitally corrected transposition of the great arteries/left ventricular outflow tract obstruction with
TLDR
Hemi-Mustard, BDG and the Rastelli procedures are technically feasible for correction of ccTGA/left ventricular outflow tract obstruction (LVOTO) and cardiac malposition and postoperative pleural effusion is the most prevalent complication in the one-stage repair. Expand
Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats.
TLDR
It is suggested that the skimmin can suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway. Expand
Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway.
TLDR
The results suggest that SAA protects cerebrovascular endothelial cells against ischemia and OGD injury via suppressing Src signaling pathway, and shows that pretreatment with SAA is a potential therapeutic strategy for the prevention of ischemic stroke. Expand
Nicousamide, a potent inhibitor of phosphorylation by TGF-β receptor II
TLDR
The results validate nicousamide as a potent inhibitor of phosphorylation of TGF -β RII and formation of cellular downstream proteins. Expand
Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases.
TLDR
Pin1 protein was shown to be overexpressed in NSCLC tumor samples, and correlated with lymph node positive disease and tumor stage, and may possibly be used as a tumor marker or as a target for cancer therapy. Expand
Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition
TLDR
Treatment with skimmin can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis. Expand
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