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PURPOSE The aim of this study was to develop a rapid, multislice cardiac T1 mapping method in mice and to apply the method to quantify manganese (Mn(2+)) uptake in a mouse model with altered Ca(2+) channel activity. METHODS An electrocardiography-triggered multislice saturation-recovery Look-Locker method was developed and validated both in vitro and in(More)
BACKGROUND Altered cardiac function has been observed in cystic fibrosis transmembrane regulator (CFTR) knockout mice. However, whether this alteration is a direct effect of CFTR disruption in the heart, or is secondary due to systemic loss of CFTR, remains to be elucidated. METHODS Cardiac function of mice with muscle-specific or global knockout of CFTR(More)
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