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Tottering, rolling Nagoya, and leaner mutant mice all exhibit cerebellar ataxia to varying degrees, from mild (tottering mice) to severe (leaner mice). Collectively, these mice are regarded as tottering locus mutants because each of these mutant mice expresses a different autosomal recessive mutation in the gene coding for the alpha(1A) calcium ion channel(More)
Direct evidence of tumour seeding in distant organs at the time of surgery for gastric cancer is not available. An immunocytochemical assay for epithelial cytokeratin protein may fill this gap since it is a feature of epithelial cells that would not normally be present in bone marrow. The bone marrow of 46 patients with primary gastric cancer was examined(More)
In order to study the pathogenesis of plasma cell dyscrasias with associated clinical features of chronic neutrophilic leukaemia, the concentration of granulocyte-colony stimulating factor (G-CSF) was measured in a patient, a 73 year old man, who underwent steroid pulse therapy. High G-CSF concentrations and leucocyte counts prior to treatment declined(More)
Voltage dependent calcium channels (VDCC) participate in regulation of neuronal Ca(2+). The Rolling mouse Nagoya (Cacna1a(tg-rol)) is a spontaneous P/Q type VDCC mutant, which has been suggested as an animal model for some human neurological diseases such as autosomal dominant cerebellar ataxia (SCA6), familial hemiplegic migraine and episodic ataxia(More)
Figure 2 Higher power image showing parent bodies enclosing several round refractile structures of varying sizes (endobodies) (haematoxylin and eosin, x450). sure of red blood cells, which had extravasate because of the congestion and vasodilatic associated with conjunctivitis, to the f released from the fat based antibiotic ointmei applied topically. It is(More)
Various types of anti-neoplastic agents induce apoptosis in vitro, but less is known of the role of this mode of cell death in tumours treated in vivo. We examined the induction of apoptosis by oral anti-neoplastic agents, tegafur and uracil (UFT, a combined preparation of 1 mol tegafur and 4 mol uracil), and the relationship of effects on tumour growth.(More)
permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract: Voltage dependent calcium channels (VDCC) participate in regulation of neuronal Ca 2+. The Rolling mouse Nagoya (Cacna1a tg-rol) is a spontaneous P/Q type VDCC mutant, which has been suggested as an animal model for(More)
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