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Tottering, rolling Nagoya, and leaner mutant mice all exhibit cerebellar ataxia to varying degrees, from mild (tottering mice) to severe (leaner mice). Collectively, these mice are regarded as tottering locus mutants because each of these mutant mice expresses a different autosomal recessive mutation in the gene coding for the alpha(1A) calcium ion channel(More)
Voltage dependent calcium channels (VDCC) participate in regulation of neuronal Ca(2+). The Rolling mouse Nagoya (Cacna1a(tg-rol)) is a spontaneous P/Q type VDCC mutant, which has been suggested as an animal model for some human neurological diseases such as autosomal dominant cerebellar ataxia (SCA6), familial hemiplegic migraine and episodic ataxia(More)
permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract: Voltage dependent calcium channels (VDCC) participate in regulation of neuronal Ca 2+. The Rolling mouse Nagoya (Cacna1a tg-rol) is a spontaneous P/Q type VDCC mutant, which has been suggested as an animal model for(More)
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