Sen Guo

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Interferon regulatory factor 8 (IRF8), a transcriptional regulator in the IRF family, has been implicated in innate immunity, immune cell differentiation and tumour cell apoptosis. In the present study, we found that IRF8 is constitutively expressed in the brain and suppressed after cerebral ischaemia in a time-dependent manner. IRF8 knockout (IRF8-KO)(More)
Among the identified thousands of circular RNAs (circRNA) in humans and animals, Cdr1as (also known as CiRS-7) was recently demonstrated to act as a powerful miR-7 sponge/inhibitor in developing midbrain of zebrafish, suggesting a novel mechanism for regulating microRNA functions. MiR-7 is abundantly expressed in islet cells, but overexpressing miR-7 in(More)
The accuracy of annual electric load forecasting plays an important role in the economic and social benefits of electric power systems. The least squares support vector machine (LSSVM) has been proven to offer strong potential in forecasting issues, particularly by employing an appropriate meta-heuristic algorithm to determine the values of its two(More)
The failure of past efforts to develop effective stroke treatments is at least partially because these treatments often interfered with essential physiological functions, even though they are targeted toward pathophysiological events, such as inflammation, excitotoxicity, and oxidative stress. Thus, the direct targeting of endogenous neuroprotective or(More)
With the growing worldwide awareness of environmental protection and sustainable development, green purchasing has become an important issue for companies to gain environmental and developmental sustainability. Thermal power is the main power generation form in China, and the green supplier selection is essential to the smooth and sustainable construction(More)
China's renewable energy power has developed rapidly in recent years. Evaluating the external benefits of renewable energy power can provide a reference for the Chinese government to set diverse development goals and to implement differentiated supporting policies for different renewable energy power types, which can promote their sustainable development.(More)
Analysis of urban saturated power loads is helpful to coordinate urban power grid construction and economic social development. There are two different kinds of forecasting models: the logistic curve model focuses on the growth law of the data itself, while the multi-dimensional forecasting model considers several influencing factors as the input variables.(More)
Accurate and reliable forecasting on annual electricity consumption will be valuable for social projectors and power grid operators. With the acceleration of electricity market reformation and the development of smart grid and the energy Internet, the modern electric power system is becoming increasingly complex in terms of structure and function.(More)
Epidermal growth factor receptor (EGFR), which is overexpressed in psoriatic lesions, has been proven to contribute to the hyperproliferation of keratinocytes in psoriasis. Single nucleotide polymorphisms (SNPs) involved in miRNAs that can regulate the expression of EGFR could potentially influence the development of psoriasis. The present study(More)