Learn More
The sensorimotor calibration of visually guided reaching changes on a trial-to-trial basis in response to random shifts in the visual feedback of the hand. We show that a simple linear dynamical system is sufficient to model the dynamics of this adaptive process. In this model, an internal variable represents the current state of sensorimotor calibration.(More)
The acquisition of new memories for places and events requires synaptic plasticity in the hippocampus, and plasticity depends on temporal coordination among neurons. Spatial activity in the hippocampus is relatively disorganized during the initial exploration of a novel environment, however, and it is unclear how neural activity during the initial stages of(More)
Recent studies have employed simple linear dynamical systems to model trial-by-trial dynamics in various sensorimotor learning tasks. Here we explore the theoretical and practical considerations that arise when employing the general class of linear dynamical systems (LDS) as a model for sensorimotor learning. In this framework, the state of the system is a(More)
Sequential activation of neurons that occurs during "offline" states, such as sleep or awake rest, is correlated with neural sequences recorded during preceding exploration phases. This so-called reactivation, or replay, has been observed in a number of different brain regions such as the striatum, prefrontal cortex, primary visual cortex and, most(More)
The microbial composition and spatial distribution in a terephthalate-degrading anaerobic granular sludge system were characterized using molecular techniques. 16S rDNA clone library and sequence analysis revealed that 78.5% of 106 bacterial clones belonged to the delta subclass of the class Proteobacteria; the remaining clones were assigned to the green(More)
The execution of action sequences is the basis of most behavior. However, little is known about the neural foundation of visuomotor sequence execution in birds, although pigeons are a classic model animal to study sequence learning and production. Recently, we identified two structures in the pigeon brain, the nidopallium intermedium medialis pars laterale(More)
Over the past four decades, a "standard framework" has emerged to explain the neural mechanisms of episodic memory storage. This framework has been instrumental in driving hippocampal research forward and now dominates the design and interpretation of experimental and theoretical studies. It postulates that cortical inputs drive plasticity in the recurrent(More)
A novel molecular probe (P2) sensing polynuclear hydrolyzed aluminum by chelation-enhanced fluorescence was described, which was prepared from 1,1'-(1,4-phenylene)bis(7-methyl-1,3,5-octanetrione) and 2-aminomethylpyridine. P2 showed a strong fluorescence response to Al(III) when excited by the optimized wavelength of 400 nm and the λ(max,em) at 505 nm(More)
In the last decades a standard model regarding the function of the hippocampus in memory formation has been established and tested computationally. It has been argued that the CA3 region works as an auto-associative memory and that its recurrent fibers are the actual storing place of the memories. Furthermore, to work properly CA3 requires memory patterns(More)