Selvarangan Ponnazhagan

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Immunization of mouse models of Alzheimer disease (AD) with amyloid-peptide (Abeta) reduces Abeta deposits and attenuates their memory and learning deficits. Recent clinical trials were halted due to meningoencephalitis, presumably induced by T cell mediated and/or Fc-mediated immune responses. Because injection of anti-Abeta F(ab')(2) antibodies also(More)
Accumulation of amyloid-β protein (Aβ) in the brain is thought to be a causal event in Alzheimer's disease (AD). Immunotherapy targeting Aβ holds great promise for reducing Aβ in the brain. Here, we evaluated the efficacy and safety of anti-Aβ single-chain antibody (scFv59) delivery via recombinant adeno-associated virus (rAAV) on reducing Aβ deposits in an(More)
This laboratory has established in previous studies that Pmel 17, a gene expressed specifically in melanocytes, maps near the silver coat color locus (si/si) on mouse chromosome 10. In the current study, we have focused on determining whether or not the si allele carries a mutation in Pmel 17. Pmel 17 cDNA clones, isolated from wild-type and si/si murine(More)
Carcinoembryonic antigen (CEA) is a cancer vaccines' target. Several features of recombinant adeno-associated virus (rAAV) are attractive for vaccine applications. Combining other viral vector vaccines with Toll-like receptor (TLR) agonists enhances antitumor immunity. Wild-type and CEA transgenic (Tg) mice were immunized with rAAV-expressing CEA, the TLR9(More)
Myeloid-derived suppressor cells (MDSC) constitute a major immunosuppressive cell population that has been correlated with poor prognosis in multiple neoplasms. MDSC are a heterogeneous population of myeloid precursors that fail to undergo maturation. MDSC exert immunosup-pressive effects through a variety of mechanisms , many of which are mediated by the(More)
Ovarian cancer remains difficult to treat mainly due to presentation of the disease at an advanced stage. Conditionally-replicating adenoviruses (CRAds) are promising anti-cancer agents that selectively kill the tumor cells. The present study evaluated the efficacy of a novel CRAd (Ad5/3-CXCR4-TIMP2) containing the CXCR4 promoter for selective viral(More)
The immunosuppressive activity exerted by myeloid-derived suppressor cells (MDSCs) in both pre-clinical tumor models and cancer patients has been intensively characterized. 1 In lung cancer, the levels of circulating MDSCs correlate positively with disease progression and immunosuppression. 2,3 Despite consistent progresses in front line therapies, lung(More)
We previously reported that anti-amyloid-beta (Aβ) single-chain antibody (scFv59) brain delivery via recombinant adeno-associated virus (rAAV) was effective in reducing cerebral Aβ load in an Alzheimer’s disease (AD) mouse model without inducing inflammation. Here, we investigated the prophylactic effects and mechanism of a muscle-directed gene therapy(More)
Anterior Gradient Protein (AGR-2) is reported to be over-expressed in many epithelial cancers and promotes metastasis. A clear-cut mechanism for its observed function(s) has not been previously identified. We found significant upregulation of AGR-2 expression in a bone metastatic prostate cancer cell line, PC3, following culturing in bone marrow-conditioned(More)
Osteolytic bone metastases are common in breast cancer (BCa). Approximately, 70% of patients dying from BCa show evidence of bone metastasis at postmor-tem examinations. The presence of such bone lesions usually signifies serious morbidity and a grave prognosis. Despite the complications deriving from bone metas-tasis, the therapies for metastatic BCa(More)
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