Selvarangan Ponnazhagan

Anandi Sawant4
Diptiman Chanda2
Gene P. Siegal2
Joo Hyoung Lee1
4Anandi Sawant
2Diptiman Chanda
2Gene P. Siegal
1Joo Hyoung Lee
1Reinhard Waehler
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This laboratory has established in previous studies that Pmel 17, a gene expressed specifically in melanocytes, maps near the silver coat color locus (si/si) on mouse chromosome 10. In the current study, we have focused on determining whether or not the si allele carries a mutation in Pmel 17. Pmel 17 cDNA clones, isolated from wild-type and si/si murine(More)
Myeloid-derived suppressor cells (MDSC) constitute a major immunosuppressive cell population that has been correlated with poor prognosis in multiple neoplasms. MDSC are a heterogeneous population of myeloid precursors that fail to undergo maturation. MDSC exert immunosup-pressive effects through a variety of mechanisms , many of which are mediated by the(More)
  • Sherry W. Yang, Diptiman Chanda, James J. Cody, Angel A. Rivera, Reinhard Waehler, Gene P. Siegal +2 others
  • 2011
Ovarian cancer remains difficult to treat mainly due to presentation of the disease at an advanced stage. Conditionally-replicating adenoviruses (CRAds) are promising anti-cancer agents that selectively kill the tumor cells. The present study evaluated the efficacy of a novel CRAd (Ad5/3-CXCR4-TIMP2) containing the CXCR4 promoter for selective viral(More)
Carcinoembryonic antigen (CEA) is a cancer vaccines' target. Several features of recombinant adeno-associated virus (rAAV) are attractive for vaccine applications. Combining other viral vector vaccines with Toll-like receptor (TLR) agonists enhances antitumor immunity. Wild-type and CEA transgenic (Tg) mice were immunized with rAAV-expressing CEA, the TLR9(More)
  • Diptiman Chanda, Joo Hyoung Lee, Anandi Sawant, Jonathan A. Hensel, Tatyana Isayeva, Stephanie D. Reilly +5 others
  • 2014
Anterior Gradient Protein (AGR-2) is reported to be over-expressed in many epithelial cancers and promotes metastasis. A clear-cut mechanism for its observed function(s) has not been previously identified. We found significant upregulation of AGR-2 expression in a bone metastatic prostate cancer cell line, PC3, following culturing in bone marrow-conditioned(More)
The immunosuppressive activity exerted by myeloid-derived suppressor cells (MDSCs) in both pre-clinical tumor models and cancer patients has been intensively characterized. 1 In lung cancer, the levels of circulating MDSCs correlate positively with disease progression and immunosuppression. 2,3 Despite consistent progresses in front line therapies, lung(More)
Osteolytic bone metastases are common in breast cancer (BCa). Approximately, 70% of patients dying from BCa show evidence of bone metastasis at postmor-tem examinations. The presence of such bone lesions usually signifies serious morbidity and a grave prognosis. Despite the complications deriving from bone metas-tasis, the therapies for metastatic BCa(More)
We previously reported that anti-amyloid-beta (Aβ) single-chain antibody (scFv59) brain delivery via recombinant adeno-associated virus (rAAV) was effective in reducing cerebral Aβ load in an Alzheimer’s disease (AD) mouse model without inducing inflammation. Here, we investigated the prophylactic effects and mechanism of a muscle-directed gene therapy(More)
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