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BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes

• G. Chinnadurai, Selvamani Vijayalingam, Ramachandran Rashmi
• Oncogene
• 2008

BIK is the founding member of the BH3-only family pro-apoptotic proteins. BIK is predominantly localized in the ER and induces apoptosis through the mitochondrial pathway by mobilizing calcium from… (More)

Genetic identification of adenovirus type 5 genes that influence viral spread.

• Thyagarajan Subramanian, Selvamani Vijayalingam, G. Chinnadurai
• Journal of virology
• 2006

The mechanisms that control cell-to-cell spread of human adenoviruses (Ad) are not well understood. Two early viral proteins, E1B-19K and E3-ADP, appear to have opposing effects since viral mutants… (More)

Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex.

• Mohan Kuppuswamy, Selvamani Vijayalingam, +4 authors G. Chinnadurai
• Molecular and cellular biology
• 2008

C-terminal binding protein (CtBP) family proteins CtBP1 and CtBP2 are highly homologous transcriptional corepressors and are recruited by a large number of transcription factors to mediate… (More)

BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

• G. Chinnadurai, Selvamani Vijayalingam, Spencer B Gibson
• Oncogene
• 2008

The BNIP3 subfamily of BH3-only proteins consists of BNIP3 and BNIP3-like (BNIP3L) proteins. These proteins form stable homodimerization complexes that localize to the outer membrane of the… (More)

Oxidative stress and the development of diabetic complications--antioxidants and lipid peroxidation in erythrocytes and cell membrane.

• A. Parthiban, Selvamani Vijayalingam, K. Shanmugasundaram, R. Mohan
• Cell biology international
• 1995

Erythrocytes isolated from 131 cases of Non-Insulin Dependent Diabetes Mellitus (NIDDM) were studied for lipid peroxidation, antioxidant defences, and the maximum peroxidisable substrate in the cell… (More)

Evidence for involvement of BH3-only proapoptotic members in adenovirus-induced apoptosis.

• Thyagarajan Subramanian, Selvamani Vijayalingam, Elena E Lomonosova, Ling Zhao, G. Chinnadurai
• Journal of virology
• 2007

Mammalian cells infected with human adenoviruses (Ads) undergo an apoptotic response as a result of expression of the viral E1A proteins, and this process is suppressed by the viral E1B-19K protein.… (More)

Evaluation of apoptogenic adenovirus type 5 oncolytic vectors in a Syrian hamster head and neck cancer model

• Selvamani Vijayalingam, Mohan Kuppusamy, +4 authors G. Chinnadurai
• Cancer Gene Therapy
• 2014

Human adenovirus (HAdV) vectors are intensely investigated for virotherapy of a wide variety of human cancers. Here, we have evaluated the effect of two apoptogenic HAdV5 vectors in an… (More)

Abnormal antioxidant status in impaired glucose tolerance and non-insulin-dependent diabetes mellitus.

• Selvamani Vijayalingam, A. Parthiban, K. Shanmugasundaram, V. Mohan
• Diabetic medicine : a journal of the British…
• 1996

A total of 105 subjects with impaired glucose tolerance were classified into two groups, 51 subjects with plasma glucose > 11.1 mmol l-1 in one of the blood samplings during OGTT, but at 2 h being… (More)

PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions

• L. X. Zhao, Thyagarajan Subramanian, Selvamani Vijayalingam, G. Chinnadurai
• Oncogene
• 2007

C-terminal binding proteins (CtBPs) are cellular corepressors that are targeted by adenovirus E1A. A conserved motif of E1A (PLDLS) interacts with an N-terminal hydrophobic cleft of CtBPs. Many… (More)

Overexpression of BH3-Only Protein BNIP3 Leads to Enhanced Tumor Growth.

• Selvamani Vijayalingam, Sreeraj G Pillai, Ramachandran Rashmi, Thyagarajan Subramanian, John E. Sagartz, G. Chinnadurai
• Genes & cancer
• 2010

BCL-2/E1B-19 kDa-interacting protein 3 (BNIP3) is a BH3-only mitochondrial protein. Expression of BNIP3 is strongly stimulated by hypoxia. Up-regulation of BNIP3 has been detected in several human… (More)

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