Sekhar Pal

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Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and(More)
Studies on interaction of tumor cells with ECM components showed increased extracellular protease activity mediated by the family of matrix metalloproteinases (MMPs). Here we studied the effect of human prostate adenocarcinoma PC-3 cells-fibronectin (FN) interaction on MMPs and the underlying signaling pathways. Culturing of PC-3 cells on FN-coated surface(More)
We have found the solution to the back reaction of putting a stack of coincident D3 and D5 branes in R 3,1 × M6, where M6 is constructed from an infinite class of Sasaki-Einstein spaces, L (p,q,r). The non-zero fluxes associated to 2 and 3-form suggests the presence of non-contractible 2 and 3-cycles in this geometry. The radial part of the warp factor has(More)
Studies on interaction of tumor cells with extracellular matrix (ECM) components showed increased extracellular protease activity mediated by the family of matrix metalloproteinases (MMPs). Here we studied the effect of human breast cancer cell line MCF-7-laminin (LM) interaction on MMPs and the underlying signaling pathways. Culturing of MCF-7 cells on LM(More)
MMPs are a family of Zn dependent endopeptidases, which can mediate degradation of ECM components during various physiological and pathological processes including cancer. Some ECM components, through interaction with integrin receptor and modulation of downstream signaling, are capable of regulating expression and activity of several MMPs. α₅β₁ integrin is(More)
We have found the solution to the back reaction of putting a stack of coincident D3 and D5 branes in R 3,1 × M6, where M6 is constructed from an infinite class of Sasaki-Einstein spaces, L (p,q,r). The non-zero fluxes associated to 2-form potential suggests the presence of a non-contractible 2-cycle in this geometry. The radial part of the warp factor has(More)
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