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Sqstm1/p62 functions in the non-canonical activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). However, its physiological relevance is not certain. Here, we show that p62(-/-) mice exhibited an accelerated presentation of ageing phenotypes, and tissues from these mice created a pro-oxidative environment owing to compromised mitochondrial(More)
Determination of model complexity is a challenging issue to solve computer vision problems using restricted boltzmann machines (RBMs). Many algorithms for feature learning depend on cross-validation or empirical methods to optimize the number of features. In this work, we propose an learning algorithm to find the optimal model complexity for the RBMs by(More)
Ribosomes synthesizing inner membrane proteins in Escherichia coli are targeted to the membrane by the signal recognition particle (SRP) pathway. By rapid kinetic analysis we show that after initial binding to the ribosome, SRP undergoes dynamic fluctuations in search of additional interactions. Non-translating ribosomes, or ribosomes synthesizing(More)
The outer-membrane protein OmpF is an abundant trimeric general diffusion porin that plays a central role in the transport of antibiotics and colicins across the outer membrane of E. coli. Individual OmpF trimers in planar lipid bilayers (PLBs) show one of two current-voltage asymmetries, thus implying that insertion occurs with either the periplasmic or(More)
Technique of comparing pedestrian images observed by different cameras to determine whether they are the same person is important in the surveillance system. This technique is called Person re-identification. Most of Person reidentification is underway assuming that occlusion does not occur. However, since occlusion occurs frequently in the surveillance(More)
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