Learn More
We investigated the capacity of a clonal osteogenic cell line MC3T3-E1, established from newborn mouse calvaria and selected on the basis of high alkaline phosphatase (ALP) activity in the confluent state, to differentiate into osteoblasts and mineralize in vitro. The cells in the growing state showed a fibroblastic morphology and grew to form multiple(More)
Hypophosphatasia (HPP) is an inherited systemic skeletal disease caused by mutations in the gene encoding the tissue-nonspecific alkaline phosphatase (TNALP) isozyme. The clinical severity of HPP varies widely, with symptoms including rickets and osteomalacia. TNALP knockout (Akp2(-/-)) mice phenotypically mimic the severe infantile form of HPP; that is,(More)
Involvement of IL-1 in tumor cell growth was first observed in subclones of a murine T cell lymphoma (1). On EBV-transformed B cell lines, including VDS-O, both IL-la and IL-I# have been reported to share the same receptor (2). This suggests that IL-1 plays a role in autocrine control of VDS-O cell proliferation , since these cells produced IL-1 and(More)
  • Vi Epcc, Rodrigo Polimeni Constantin, Renato Polimeni, Constantin Cristiane, Vizioli De Castro, Nair +1 other
  • 2009
Flavonoids have been proposed to exert beneficial effects in a multitude of disease states, including cancer, cardiovascular disease, and neurodegenerative disorders. The most known biological effects of the flavonoids, is no doubt their antioxidant action, which represents protection of tissues against the action of free-radicals and diminution of lipid(More)
A 14-year-old girl was diagnosed as having herpes simplex encephalitis by a polymerase chain reaction examination of the cerebrospinal fluid. MRI showed diffuse high signal areas at the bilateral temporal lobes and right frontal lobe. She was treated with a total of 350 mg/kg of acyclovir for 23 days, and discharged without abnormal neurological findings.(More)
  • 1